5 recherche sur le tag 'anticancer'   

Metal-based anticancer agents / Casini, Angela

Public ISBD Titre : Metal-based anticancer agents Type de document : texte imprimé Auteurs : Casini, Angela, Auteur ; Vessières, Anne, Auteur ; Meier-Menches, Samuel, Auteur Editeur : Cambridge : RSC Publishing Année de publication : 2019 Collection : Metallobiology num. 14 Importance : xiii, 355 p. ISBN/ISSN/EAN : 978-1-78801-406-9 Langues : Anglais (eng) Catégories : Biochimie Tags : ANTICANCER Index. décimale : B-F Résumé : Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. Note de contenu : "* Enhancing the Therapeutic Potential of Platinum-based Anticancer Agents by Incorporating Clinically Approved Drugs as Ligands * Ruthenium, Osmium and Iridium in the Fight Against Cancer * Iron Compounds as Anticancer Agents * Anticancer Gold Compounds * Heterometallic Complexes as Anticancer Agents * Vanadium Compounds as Enzyme Inhibitors with a Focus on Anticancer Effects * Arsenic-based Anticancer Agents * Supramolecular Metal-based Structures for Applications in Cancer Therapy * Enabling Methods to Elucidate the Effects of Metal-based Anticancer Agents * Metal-based Radiotherapeutics * Challenges and Chances in the Preclinical to Clinical Translation of Anticancer Metallodrugs". Cote : B-F061 Num_Inv : 715 Localisation : LCC (SdS) Metal-based anticancer agents [texte imprimé] / Casini, Angela, Auteur ; Vessières, Anne, Auteur ; Meier-Menches, Samuel, Auteur . - Cambridge : RSC Publishing, 2019 . - xiii, 355 p.. - (Metallobiology; 14) . ISBN : 978-1-78801-406-9 Langues : Anglais (eng) Catégories : Biochimie Tags : ANTICANCER Index. décimale : B-F Résumé : Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. Note de contenu : "* Enhancing the Therapeutic Potential of Platinum-based Anticancer Agents by Incorporating Clinically Approved Drugs as Ligands * Ruthenium, Osmium and Iridium in the Fight Against Cancer * Iron Compounds as Anticancer Agents * Anticancer Gold Compounds * Heterometallic Complexes as Anticancer Agents * Vanadium Compounds as Enzyme Inhibitors with a Focus on Anticancer Effects * Arsenic-based Anticancer Agents * Supramolecular Metal-based Structures for Applications in Cancer Therapy * Enabling Methods to Elucidate the Effects of Metal-based Anticancer Agents * Metal-based Radiotherapeutics * Challenges and Chances in the Preclinical to Clinical Translation of Anticancer Metallodrugs". Cote : B-F061 Num_Inv : 715 Localisation : LCC (SdS)

Exemplaires(1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
715	B-F061	Texte imprimé	Bibliothèque	Livre	Disponible

Synthesis of N-heterocyclic carbene gold(I) complexes: Towards the development of new organometallic drugs / Luca Boselli  

Public ISBD Titre : Synthesis of N-heterocyclic carbene gold(I) complexes: Towards the development of new organometallic drugs Type de document : texte imprimé Auteurs : Luca Boselli, Auteur ; Heinz Gornitzka, Directeur de thèse ; Catherine Hemmert, Directeur de thèse Année de publication : 2014 Langues : Anglais (eng) Tags : METALLODRUG  ANTICANCER  GOLD COMPLEX  CARBENE COMPLEX Résumé : "Biomedical applications of gold complexes based on N-heterocyclic carbenes (NHCs) are beginning to unfold. Some cationic gold(I) NHCs complexes show antimitochondrial activities, a very promising action mode in the fight against cancer; due to their positive charge these complexes target preferentially tumor cells, leading to cell death. In this work of thesis, three groups of new NHC-based gold and heterobimetallic complexes involving aliphatic or aromatic amino-functionalized NHCs with interesting potential in biomedical research have been synthetized and characterized. The first group is formed by three luminescent heterobimetallic gold(I)-ruthenium(II) complexes containing heteroditopic bipyridine-NHC ligands. These compounds have been biologically investigated by in vitro tests for their antitumoral, antileishmanial and antimalarial activities. Finally, imaging studies in cancer cells have been performed exploiting the luminescent properties of the most active compound. The second group of molecules is concerned by cationic gold(I) complexes containing two 1[2-(diethylamino)ethyl]imidazolydene ligands. First the complexes have been tested for their antiproliferative activity in prostate cancer cell line PC-3. Lipophilicity (Log P) has been determined for these complexes. The most active complex has been tested for the cytotoxic activities in five human cancer cell lines and primary endothelial cells demonstrating a potent action and selectivity for cancer cells. In addition, antileishmanial and antimalarial activities of these compounds have been investigated showing interesting results. The third group is formed by a hetero-dinuclear gold(I)-silver(I) and a trinuclear gold(I)-copper(II) complexes containing phenanthroline-NHC ligands. The compounds are formed by two different organometallic units potentially able to act as multi-targeting anticancer drug." Document : Thèse de doctorat Etablissement_delivrance : Université de Toulouse 3 Date_soutenance : 04/12/2014 Ecole_doctorale : Science de la matière (université Toulouse III P. Sabatier) Domaine : Chimie organométallique de coordination Localisation : LCC En ligne : http://thesesups.ups-tlse.fr/2579/ Synthesis of N-heterocyclic carbene gold(I) complexes: Towards the development of new organometallic drugs [texte imprimé] / Luca Boselli, Auteur ; Heinz Gornitzka, Directeur de thèse ; Catherine Hemmert, Directeur de thèse . - 2014. Langues : Anglais (eng) Tags : METALLODRUG  ANTICANCER  GOLD COMPLEX  CARBENE COMPLEX Résumé : "Biomedical applications of gold complexes based on N-heterocyclic carbenes (NHCs) are beginning to unfold. Some cationic gold(I) NHCs complexes show antimitochondrial activities, a very promising action mode in the fight against cancer; due to their positive charge these complexes target preferentially tumor cells, leading to cell death. In this work of thesis, three groups of new NHC-based gold and heterobimetallic complexes involving aliphatic or aromatic amino-functionalized NHCs with interesting potential in biomedical research have been synthetized and characterized. The first group is formed by three luminescent heterobimetallic gold(I)-ruthenium(II) complexes containing heteroditopic bipyridine-NHC ligands. These compounds have been biologically investigated by in vitro tests for their antitumoral, antileishmanial and antimalarial activities. Finally, imaging studies in cancer cells have been performed exploiting the luminescent properties of the most active compound. The second group of molecules is concerned by cationic gold(I) complexes containing two 1[2-(diethylamino)ethyl]imidazolydene ligands. First the complexes have been tested for their antiproliferative activity in prostate cancer cell line PC-3. Lipophilicity (Log P) has been determined for these complexes. The most active complex has been tested for the cytotoxic activities in five human cancer cell lines and primary endothelial cells demonstrating a potent action and selectivity for cancer cells. In addition, antileishmanial and antimalarial activities of these compounds have been investigated showing interesting results. The third group is formed by a hetero-dinuclear gold(I)-silver(I) and a trinuclear gold(I)-copper(II) complexes containing phenanthroline-NHC ligands. The compounds are formed by two different organometallic units potentially able to act as multi-targeting anticancer drug." Document : Thèse de doctorat Etablissement_delivrance : Université de Toulouse 3 Date_soutenance : 04/12/2014 Ecole_doctorale : Science de la matière (université Toulouse III P. Sabatier) Domaine : Chimie organométallique de coordination Localisation : LCC En ligne : http://thesesups.ups-tlse.fr/2579/

Platinum coordination complexes in cancer chemotherapy / Hacker, Miles P.

Public ISBD Titre : Platinum coordination complexes in cancer chemotherapy Type de document : texte imprimé Auteurs : Hacker, Miles P., Auteur ; Douple, Evan B., Auteur ; Krakoff, Irwin H., Auteur Editeur : Martinus Nijhoff Publishing Année de publication : 1984 Collection : Developments in oncology Importance : xiv, 384 p. ISBN/ISSN/EAN : 978-0-89838-619-6 Langues : Anglais (eng) Catégories : Biochimie Tags : ANTICANCER  CANCER CHEMOTHERAPY Index. décimale : B-F Cote : B-F024 Num_Inv : 1416 Localisation : LCC (SdS) Platinum coordination complexes in cancer chemotherapy [texte imprimé] / Hacker, Miles P., Auteur ; Douple, Evan B., Auteur ; Krakoff, Irwin H., Auteur . - Martinus Nijhoff Publishing, 1984 . - xiv, 384 p.. - (Developments in oncology) . ISBN : 978-0-89838-619-6 Langues : Anglais (eng) Catégories : Biochimie Tags : ANTICANCER  CANCER CHEMOTHERAPY Index. décimale : B-F Cote : B-F024 Num_Inv : 1416 Localisation : LCC (SdS)

Exemplaires(1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
1416	B-F024	Texte imprimé	Bibliothèque	Livre	Disponible