Design, synthesis and photochemical study of ruthenium nitrosyls and BODIPYcarborane conjugates for possible applications in cell imaging and therapy / Pablo Labra-Vázquez  

Public ISBD Titre : Design, synthesis and photochemical study of ruthenium nitrosyls and BODIPYcarborane conjugates for possible applications in cell imaging and therapy Type de document : texte imprimé Auteurs : Pablo Labra-Vázquez, Auteur ; Norberto Farfán, Directeur de thèse ; Lacroix, Pascal, Directeur de thèse Langues : Anglais (eng) Langues originales : Espagnol (spa) Tags : CARBORANE  RUTHENIUM  NITROSYL  TERPYRIDINE  PACT  BNCT Résumé : "Photoactivated chemotherapy (PACT) is a therapeutic approach based on the photo-induced release of a toxic molecule capable of producing cell death; as the toxicity of the molecule is triggered locally by light, PACT provides an elegant way to destroy cancer cells without damaging nearby healthy tissues. In this context, our research group has been developing ruthenium nitrosyl complexes (RuNO) with polypyridyl ligands which are capable of releasing NO• via two-photon absorption (TPA). In Chapter I, after reviewing the state of the art of PACT, the evaluation of the influence of the introduction of a thienyl ring in the polypyridyl ligand is described as a strategy to improve the two-photon absorption cross sections of the complexes. Chapter II focuses on Boron Neutron Capture Therapy (BNCT), a type of radiation therapy in which the ionizing energy that produces cell death is generated by the fission of 10B nuclei after irradiation with low energy neutrons. Because cell death is restricted to boron-enriched cells, BNCT provides the ability to selectively treat tumors, minimizing damage to nearby healthy tissues. Due to their high boron contents, carboranes (polyhedral carbonboron clusters) are ideal candidates for BNCT. After a comprehensive analysis of the state of the art of BNCT, we present the synthesis, chemical and photochemical characterization, and the study of cell entry on HeLa cells for a group of carboranes functionalized with BODIPY fluorophores. The results show that lipophilicity and the dipole moment have an important influence on the ease with which the fluorophores studied permeate to the intracellular media, thus providing an explanation for the divergent cellular permeability that this type of compounds usually show." Document : Thèse de Doctorat Etablissement_delivrance : Universté Toulouse 3 avec Cotutelle internationale : Universidad Nacional Autónoma de México Date_soutenance : 20/10/2020 Ecole_doctorale : Sciences de la matière (SdM) (Toulouse) Domaine : Chimie Organométallique et de Coordination En ligne : http://thesesups.ups-tlse.fr/4828/ Design, synthesis and photochemical study of ruthenium nitrosyls and BODIPYcarborane conjugates for possible applications in cell imaging and therapy [texte imprimé] / Pablo Labra-Vázquez, Auteur ; Norberto Farfán, Directeur de thèse ; Lacroix, Pascal, Directeur de thèse . - [s.d.]. Langues : Anglais (eng) Langues originales : Espagnol (spa) Tags : CARBORANE  RUTHENIUM  NITROSYL  TERPYRIDINE  PACT  BNCT Résumé : "Photoactivated chemotherapy (PACT) is a therapeutic approach based on the photo-induced release of a toxic molecule capable of producing cell death; as the toxicity of the molecule is triggered locally by light, PACT provides an elegant way to destroy cancer cells without damaging nearby healthy tissues. In this context, our research group has been developing ruthenium nitrosyl complexes (RuNO) with polypyridyl ligands which are capable of releasing NO• via two-photon absorption (TPA). In Chapter I, after reviewing the state of the art of PACT, the evaluation of the influence of the introduction of a thienyl ring in the polypyridyl ligand is described as a strategy to improve the two-photon absorption cross sections of the complexes. Chapter II focuses on Boron Neutron Capture Therapy (BNCT), a type of radiation therapy in which the ionizing energy that produces cell death is generated by the fission of 10B nuclei after irradiation with low energy neutrons. Because cell death is restricted to boron-enriched cells, BNCT provides the ability to selectively treat tumors, minimizing damage to nearby healthy tissues. Due to their high boron contents, carboranes (polyhedral carbonboron clusters) are ideal candidates for BNCT. After a comprehensive analysis of the state of the art of BNCT, we present the synthesis, chemical and photochemical characterization, and the study of cell entry on HeLa cells for a group of carboranes functionalized with BODIPY fluorophores. The results show that lipophilicity and the dipole moment have an important influence on the ease with which the fluorophores studied permeate to the intracellular media, thus providing an explanation for the divergent cellular permeability that this type of compounds usually show." Document : Thèse de Doctorat Etablissement_delivrance : Universté Toulouse 3 avec Cotutelle internationale : Universidad Nacional Autónoma de México Date_soutenance : 20/10/2020 Ecole_doctorale : Sciences de la matière (SdM) (Toulouse) Domaine : Chimie Organométallique et de Coordination En ligne : http://thesesups.ups-tlse.fr/4828/

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