Cancer chemotherapy reports. Part 2, vol.4 n°2 : Structure antitumor activity relationships among quinone derivatives / John S. Driscoll

Public ISBD Titre : Cancer chemotherapy reports. Part 2, vol.4 n°2 : Structure antitumor activity relationships among quinone derivatives Type de document : texte imprimé Auteurs : John S. Driscoll ; George F. Hazard ; Harry B. Wood, Éditeur scientifique ; Abraham Goldin, Éditeur scientifique Editeur : Bethesda : National Institute of Health Année de publication : 1974 Importance : 363 p. Langues : Anglais (eng) Catégories : Biochimie Tags : CANCER DRUG THERAPY  QUINONES-Therapeutic use Index. décimale : B-F Résumé : "This report is part of a continuing effort by the National Cancer Institute (NCI) to summarize animal antitumor screening data for selected classes of compounds and to relate this activity to chemical structure. Nucleoside, folic acid, and methanesulfonate derivatives have been treated previously. Quinones play significant roles in many areas of chemistry and biochemistry and many derivatives have been synthesized for study. Because of their availability and the biologic properties known to be associated with the quinone structure, a large number of these compounds have been screened over the past 17 years in the NCI's Drug Research and Development program aimed at the discovery of leads to new classes of antitumor drugs. This report is a summary and an analysis of animal antitumor data for the quinone derivatives evaluated by the NCI. While general structure activity relationships and conclusions are drawn, more detailed analyses (both qualitative and quantitative) are possible. It is hoped that this review will be useful to investigators who are interested in further studies of antitumor agents in general and quinone derivatives in particular." Cote : B-F031 (SdS) Num_Inv : 2409 Cancer chemotherapy reports. Part 2, vol.4 n°2 : Structure antitumor activity relationships among quinone derivatives [texte imprimé] / John S. Driscoll ; George F. Hazard ; Harry B. Wood, Éditeur scientifique ; Abraham Goldin, Éditeur scientifique . - Bethesda : National Institute of Health, 1974 . - 363 p. Langues : Anglais (eng) Catégories : Biochimie Tags : CANCER DRUG THERAPY  QUINONES-Therapeutic use Index. décimale : B-F Résumé : "This report is part of a continuing effort by the National Cancer Institute (NCI) to summarize animal antitumor screening data for selected classes of compounds and to relate this activity to chemical structure. Nucleoside, folic acid, and methanesulfonate derivatives have been treated previously. Quinones play significant roles in many areas of chemistry and biochemistry and many derivatives have been synthesized for study. Because of their availability and the biologic properties known to be associated with the quinone structure, a large number of these compounds have been screened over the past 17 years in the NCI's Drug Research and Development program aimed at the discovery of leads to new classes of antitumor drugs. This report is a summary and an analysis of animal antitumor data for the quinone derivatives evaluated by the NCI. While general structure activity relationships and conclusions are drawn, more detailed analyses (both qualitative and quantitative) are possible. It is hoped that this review will be useful to investigators who are interested in further studies of antitumor agents in general and quinone derivatives in particular." Cote : B-F031 (SdS) Num_Inv : 2409

Exemplaires(1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
2409	B-F031	Texte imprimé	Bibliothèque	Livre	Disponible

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