Nouveaux complexes de bases de Schiff chirales macrocycliques de manganèse pour l'époxydation asymétrique d'oléfines / Martinez, Alexandre

Public ISBD Titre : Nouveaux complexes de bases de Schiff chirales macrocycliques de manganèse pour l'époxydation asymétrique d'oléfines Type de document : texte imprimé Auteurs : Martinez, Alexandre ; Bernard Meunier, Directeur de thèse ; Catherine Hemmert, Directeur de thèse ; Remi Chauvin, Directeur de thèse Année de publication : 2004 Langues : Français (fre) Document : Thèse de doctorat Etablissement_delivrance : Université de Toulouse Date_soutenance : 23/09/2004 Localisation : LCC Nouveaux complexes de bases de Schiff chirales macrocycliques de manganèse pour l'époxydation asymétrique d'oléfines [texte imprimé] / Martinez, Alexandre ; Bernard Meunier, Directeur de thèse ; Catherine Hemmert, Directeur de thèse ; Remi Chauvin, Directeur de thèse . - 2004. Langues : Français (fre) Document : Thèse de doctorat Etablissement_delivrance : Université de Toulouse Date_soutenance : 23/09/2004 Localisation : LCC

Synthesis of N-heterocyclic carbene gold(I) complexes: Towards the development of new organometallic drugs / Luca Boselli  

Public ISBD Titre : Synthesis of N-heterocyclic carbene gold(I) complexes: Towards the development of new organometallic drugs Type de document : texte imprimé Auteurs : Luca Boselli ; Heinz Gornitzka, Directeur de thèse ; Catherine Hemmert, Directeur de thèse Année de publication : 2014 Langues : Anglais (eng) Tags : METALLODRUG  ANTICANCER  GOLD COMPLEX  CARBENE COMPLEX Résumé : Biomedical applications of gold complexes based on N-heterocyclic carbenes (NHCs) are beginning to unfold. Some cationic gold(I) NHCs complexes show antimitochondrial activities, a very promising action mode in the fight against cancer; due to their positive charge these complexes target preferentially tumor cells, leading to cell death. In this work of thesis, three groups of new NHC-based gold and heterobimetallic complexes involving aliphatic or aromatic amino-functionalized NHCs with interesting potential in biomedical research have been synthetized and characterized. The first group is formed by three luminescent heterobimetallic gold(I)-ruthenium(II) complexes containing heteroditopic bipyridine-NHC ligands. These compounds have been biologically investigated by in vitro tests for their antitumoral, antileishmanial and antimalarial activities. Finally, imaging studies in cancer cells have been performed exploiting the luminescent properties of the most active compound. The second group of molecules is concerned by cationic gold(I) complexes containing two 1[2-(diethylamino)ethyl]imidazolydene ligands. First the complexes have been tested for their antiproliferative activity in prostate cancer cell line PC-3. Lipophilicity (Log P) has been determined for these complexes. The most active complex has been tested for the cytotoxic activities in five human cancer cell lines and primary endothelial cells demonstrating a potent action and selectivity for cancer cells. In addition, antileishmanial and antimalarial activities of these compounds have been investigated showing interesting results. The third group is formed by a hetero-dinuclear gold(I)-silver(I) and a trinuclear gold(I)-copper(II) complexes containing phenanthroline-NHC ligands. The compounds are formed by two different organometallic units potentially able to act as multi-targeting anticancer drug. Document : Thèse de doctorat Etablissement_delivrance : Université de Toulouse Date_soutenance : 04/12/2014 Ecole_doctorale : Science de la matière (université Toulouse III P. Sabatier) Domaine : Chimie organométallique de coordination Localisation : LCC En ligne : http://thesesups.ups-tlse.fr/2579/ Synthesis of N-heterocyclic carbene gold(I) complexes: Towards the development of new organometallic drugs [texte imprimé] / Luca Boselli ; Heinz Gornitzka, Directeur de thèse ; Catherine Hemmert, Directeur de thèse . - 2014. Langues : Anglais (eng) Tags : METALLODRUG  ANTICANCER  GOLD COMPLEX  CARBENE COMPLEX Résumé : Biomedical applications of gold complexes based on N-heterocyclic carbenes (NHCs) are beginning to unfold. Some cationic gold(I) NHCs complexes show antimitochondrial activities, a very promising action mode in the fight against cancer; due to their positive charge these complexes target preferentially tumor cells, leading to cell death. In this work of thesis, three groups of new NHC-based gold and heterobimetallic complexes involving aliphatic or aromatic amino-functionalized NHCs with interesting potential in biomedical research have been synthetized and characterized. The first group is formed by three luminescent heterobimetallic gold(I)-ruthenium(II) complexes containing heteroditopic bipyridine-NHC ligands. These compounds have been biologically investigated by in vitro tests for their antitumoral, antileishmanial and antimalarial activities. Finally, imaging studies in cancer cells have been performed exploiting the luminescent properties of the most active compound. The second group of molecules is concerned by cationic gold(I) complexes containing two 1[2-(diethylamino)ethyl]imidazolydene ligands. First the complexes have been tested for their antiproliferative activity in prostate cancer cell line PC-3. Lipophilicity (Log P) has been determined for these complexes. The most active complex has been tested for the cytotoxic activities in five human cancer cell lines and primary endothelial cells demonstrating a potent action and selectivity for cancer cells. In addition, antileishmanial and antimalarial activities of these compounds have been investigated showing interesting results. The third group is formed by a hetero-dinuclear gold(I)-silver(I) and a trinuclear gold(I)-copper(II) complexes containing phenanthroline-NHC ligands. The compounds are formed by two different organometallic units potentially able to act as multi-targeting anticancer drug. Document : Thèse de doctorat Etablissement_delivrance : Université de Toulouse Date_soutenance : 04/12/2014 Ecole_doctorale : Science de la matière (université Toulouse III P. Sabatier) Domaine : Chimie organométallique de coordination Localisation : LCC En ligne : http://thesesups.ups-tlse.fr/2579/

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