Titre :	Cancer chemotherapy reports. Part 2, vol.4 n°2 : Structure antitumor activity relationships among quinone derivatives
Type de document :	texte imprimé
Auteurs :	John S. Driscoll ; George F. Hazard ; Harry B. Wood, Éditeur scientifique ; Abraham Goldin, Éditeur scientifique
Editeur :	Bethesda : National Institute of Health
Année de publication :	1974
Importance :	363 p.
Langues :	Anglais (eng)
Catégories :	Biochimie
Tags :	CANCER DRUG THERAPY  QUINONES-Therapeutic use
Index. décimale :	B-F
Résumé :	"This report is part of a continuing effort by the National Cancer Institute (NCI) to summarize animal antitumor screening data for selected classes of compounds and to relate this activity to chemical structure. Nucleoside, folic acid, and methanesulfonate derivatives have been treated previously. Quinones play significant roles in many areas of chemistry and biochemistry and many derivatives have been synthesized for study. Because of their availability and the biologic properties known to be associated with the quinone structure, a large number of these compounds have been screened over the past 17 years in the NCI's Drug Research and Development program aimed at the discovery of leads to new classes of antitumor drugs. This report is a summary and an analysis of animal antitumor data for the quinone derivatives evaluated by the NCI. While general structure activity relationships and conclusions are drawn, more detailed analyses (both qualitative and quantitative) are possible. It is hoped that this review will be useful to investigators who are interested in further studies of antitumor agents in general and quinone derivatives in particular."
Cote :	B-F031 (SdS)
Num_Inv :	2409

Cancer chemotherapy reports. Part 2, vol.4 n°2 : Structure antitumor activity relationships among quinone derivatives [texte imprimé] / John S. Driscoll ; George F. Hazard ; Harry B. Wood, Éditeur scientifique ; Abraham Goldin, Éditeur scientifique . - Bethesda : National Institute of Health, 1974 . - 363 p.
Langues : Anglais (eng)

Catégories :	Biochimie
Tags :	CANCER DRUG THERAPY  QUINONES-Therapeutic use
Index. décimale :	B-F
Résumé :	"This report is part of a continuing effort by the National Cancer Institute (NCI) to summarize animal antitumor screening data for selected classes of compounds and to relate this activity to chemical structure. Nucleoside, folic acid, and methanesulfonate derivatives have been treated previously. Quinones play significant roles in many areas of chemistry and biochemistry and many derivatives have been synthesized for study. Because of their availability and the biologic properties known to be associated with the quinone structure, a large number of these compounds have been screened over the past 17 years in the NCI's Drug Research and Development program aimed at the discovery of leads to new classes of antitumor drugs. This report is a summary and an analysis of animal antitumor data for the quinone derivatives evaluated by the NCI. While general structure activity relationships and conclusions are drawn, more detailed analyses (both qualitative and quantitative) are possible. It is hoped that this review will be useful to investigators who are interested in further studies of antitumor agents in general and quinone derivatives in particular."
Cote :	B-F031 (SdS)
Num_Inv :	2409