Titre :	Combinatorial chemistry : Synthesis, analysis, screening
Type de document :	texte imprimé
Auteurs :	Jung, Günther, Éditeur scientifique
Editeur :	Oxford : Wiley
Année de publication :	1999
Importance :	634 p.
ISBN/ISSN/EAN :	978-3-527-29869-3
Langues :	Anglais (eng)
Catégories :	Chimie de coordination, Chimie organométallique, Métaux de transition
Tags :	BIOCHEMISTRY  APPLICATIONS  ORGANOMETALLIC-SYNTHESIS
Index. décimale :	B-D
Résumé :	Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book, edited by Günther Jung: The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry.
Note de contenu :	"* Combinatorial Chemistry Survey of Solid?Phase Organic Reactions Solution?Phase Combinatorial Chemistry Combinatorial Chemistry of Multicomponent Reactions Solid?Phase Anchors in Organic Chemistry The Use of Templates in Combinatorial Chemistry for the Solid?Phase Synthesis of Multiple Core Structure Libraries Combinatorial Synthetic Oligomers Glycopeptide and Oligosaccharide Libraries RNA and DNA Aptamers Combinatorial Approaches to Molecular Receptors for Chemosensors Peptide Libraries in T?Cell?Mediated Immune Response Combinatorial Biosynthesis of Microbial Metabolites Design and Diversity Analysis of Compound Libraries for Lead Discovery How to Scale?up while Scaling down: EVOscreen™, a Miniaturized Ultra?High?Throughput Screening System High?Throughput Experimentation in Catalysis FT?Infrared Spectroscopy and IR?Microscopy On?Bead Analysis of Solid?Phase Synthesis Mass Spectrometric Analysis of Combinatorially Generated Compounds and Libraries High?Resolution Magic Angle Spinning (MAS) NMR Spectroscopy for On?Bead Analysis of Solid?Phase Synthesis Automated Combinatorial Chemistry Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT?ICR?MS) for Analysis of Compound Libraries".
Cote :	B-D207
Num_Inv :	3595
Localisation :	LCC (SdS)

Combinatorial chemistry : Synthesis, analysis, screening [texte imprimé] / Jung, Günther, Éditeur scientifique . - Oxford : Wiley, 1999 . - 634 p.
ISBN : 978-3-527-29869-3
Langues : Anglais (eng)

Catégories :	Chimie de coordination, Chimie organométallique, Métaux de transition
Tags :	BIOCHEMISTRY  APPLICATIONS  ORGANOMETALLIC-SYNTHESIS
Index. décimale :	B-D
Résumé :	Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book, edited by Günther Jung: The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry.
Note de contenu :	"* Combinatorial Chemistry Survey of Solid?Phase Organic Reactions Solution?Phase Combinatorial Chemistry Combinatorial Chemistry of Multicomponent Reactions Solid?Phase Anchors in Organic Chemistry The Use of Templates in Combinatorial Chemistry for the Solid?Phase Synthesis of Multiple Core Structure Libraries Combinatorial Synthetic Oligomers Glycopeptide and Oligosaccharide Libraries RNA and DNA Aptamers Combinatorial Approaches to Molecular Receptors for Chemosensors Peptide Libraries in T?Cell?Mediated Immune Response Combinatorial Biosynthesis of Microbial Metabolites Design and Diversity Analysis of Compound Libraries for Lead Discovery How to Scale?up while Scaling down: EVOscreen™, a Miniaturized Ultra?High?Throughput Screening System High?Throughput Experimentation in Catalysis FT?Infrared Spectroscopy and IR?Microscopy On?Bead Analysis of Solid?Phase Synthesis Mass Spectrometric Analysis of Combinatorially Generated Compounds and Libraries High?Resolution Magic Angle Spinning (MAS) NMR Spectroscopy for On?Bead Analysis of Solid?Phase Synthesis Automated Combinatorial Chemistry Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT?ICR?MS) for Analysis of Compound Libraries".
Cote :	B-D207
Num_Inv :	3595
Localisation :	LCC (SdS)