Titre :	Novel intramolecular diastereoselective flp-type activation for aldehydes
Type de document :	texte imprimé
Auteurs :	Angelica Mejia Fajardo, Auteur ; Sebastien Bontemps, Directeur de thèse
Année de publication :	2021
Langues :	Anglais (eng)
Tags :	FLP  ALDEHYDES  SMALL MOLECULES  DIASTEREOSELECTIVITY  BRESLOW INTERMEDIATE
Résumé :	"Frustrated Lewis Pairs systems (FLP) are a new concept in green chemistry due to their ability to function as free metal catalyst activation such as hydrogen, carbon dioxide, aldehydes, and all kinds of small molecules. The present document seeks to study the reactivity and potential use of a molecule as a masked FLP that, in its inner features, includes a nonclassical carbon-based Lewis base that is not coming from a carbene, and a borane as Lewis acid (compound 1). Three parts were developed into this analysis strategy. The first was the reactivity study of various small molecule types on the system. The second part was to comprehend the benzaldehyde adduct reaction, identifying that the use of 1 enabled access to an O-Borylated Breslow intermediate as an FLP system for the product. In the third part, benzaldehyde adduct reaction was taken as a reference model to develop a methodology to be extended to other aldehydes. It has been proved that compound 1: is a novel intramolecular masked FLP system with unique features; is chemoselective to activate aldehydes; has unprecedented diastereoselectivity, and this study brings original insights about the kinetics and the reaction mechanism."
Document :	Thèse de Doctorat
Etablissement_delivrance :	Université Toulouse 3
Date_soutenance :	18/05/2021
Ecole_doctorale :	Sciences de la matière (SdM) (Toulouse)
Domaine :	Chimie Organométallique et de Coordination
Localisation :	LCC
En ligne :	http://thesesups.ups-tlse.fr/5311/

Novel intramolecular diastereoselective flp-type activation for aldehydes [texte imprimé] / Angelica Mejia Fajardo, Auteur ; Sebastien Bontemps, Directeur de thèse . - 2021.
Langues : Anglais (eng)

Tags :	FLP  ALDEHYDES  SMALL MOLECULES  DIASTEREOSELECTIVITY  BRESLOW INTERMEDIATE
Résumé :	"Frustrated Lewis Pairs systems (FLP) are a new concept in green chemistry due to their ability to function as free metal catalyst activation such as hydrogen, carbon dioxide, aldehydes, and all kinds of small molecules. The present document seeks to study the reactivity and potential use of a molecule as a masked FLP that, in its inner features, includes a nonclassical carbon-based Lewis base that is not coming from a carbene, and a borane as Lewis acid (compound 1). Three parts were developed into this analysis strategy. The first was the reactivity study of various small molecule types on the system. The second part was to comprehend the benzaldehyde adduct reaction, identifying that the use of 1 enabled access to an O-Borylated Breslow intermediate as an FLP system for the product. In the third part, benzaldehyde adduct reaction was taken as a reference model to develop a methodology to be extended to other aldehydes. It has been proved that compound 1: is a novel intramolecular masked FLP system with unique features; is chemoselective to activate aldehydes; has unprecedented diastereoselectivity, and this study brings original insights about the kinetics and the reaction mechanism."
Document :	Thèse de Doctorat
Etablissement_delivrance :	Université Toulouse 3
Date_soutenance :	18/05/2021
Ecole_doctorale :	Sciences de la matière (SdM) (Toulouse)
Domaine :	Chimie Organométallique et de Coordination
Localisation :	LCC
En ligne :	http://thesesups.ups-tlse.fr/5311/