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Titre de série : |
Comprehensive Chirality |
Titre : |
Vol.1 : Biological significance – pharmacology, phamaceutical, agrochemical |
Type de document : |
texte imprimé |
Auteurs : |
Erick M. Carreira, Éditeur scientifique ; Hisashi Yamamoto, Éditeur scientifique ; Janine R. Cossy, Éditeur scientifique |
Editeur : |
Amsterdam : Elsevier |
Année de publication : |
2012 |
Collection : |
Comprehensive Chirality  |
Importance : |
xxvi, 245 p. |
Format : |
28 cm |
ISBN/ISSN/EAN : |
978-0-08-095167-6 |
Langues : |
Anglais (eng) |
Note de contenu : |
"* Introduction: The importance of chirality in drugs and agrochemicals
* Importance of chirality in the field of anti-infective agents
* Chirality in antibacterial agents
* Diastereomers, enantiomers and bioactivity. TMC207: A new candidate for the treatment of tuberculosis
* Fluorine in medicinal chemistry: Importance of chirality
* Peptides and chirality effects on the conformation and the synthesis of medicinally relevant peptides
* Stereochemical lability in drug molecules: Cases where chirality may not be critical for drug development
* Chirality in agrochemicals
* The use of new phosphines as powerful tools in asymmetric synthesis of biologically active compounds
* Chirality and combinatorial libraries for drug discovery, an overview." |
Cote : |
EXCLU (SdL) |
Num_Inv : |
3290 |
Comprehensive Chirality. Vol.1 : Biological significance – pharmacology, phamaceutical, agrochemical [texte imprimé] / Erick M. Carreira, Éditeur scientifique ; Hisashi Yamamoto, Éditeur scientifique ; Janine R. Cossy, Éditeur scientifique . - Amsterdam : Elsevier, 2012 . - xxvi, 245 p. ; 28 cm. - ( Comprehensive Chirality) . ISBN : 978-0-08-095167-6 Langues : Anglais ( eng)
Note de contenu : |
"* Introduction: The importance of chirality in drugs and agrochemicals
* Importance of chirality in the field of anti-infective agents
* Chirality in antibacterial agents
* Diastereomers, enantiomers and bioactivity. TMC207: A new candidate for the treatment of tuberculosis
* Fluorine in medicinal chemistry: Importance of chirality
* Peptides and chirality effects on the conformation and the synthesis of medicinally relevant peptides
* Stereochemical lability in drug molecules: Cases where chirality may not be critical for drug development
* Chirality in agrochemicals
* The use of new phosphines as powerful tools in asymmetric synthesis of biologically active compounds
* Chirality and combinatorial libraries for drug discovery, an overview." |
Cote : |
EXCLU (SdL) |
Num_Inv : |
3290 |
|  |
Exemplaires(1)
3290
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EXCLU |
Texte imprimé |
Salle de lecture |
Encyclopédie
|
Consultation sur place Exclu du prêt |

Titre de série : |
Comprehensive Chirality |
Titre : |
Vol.2 : Synthetic methods I – Chiral pool and diastereoselective methods |
Type de document : |
texte imprimé |
Auteurs : |
Erick M. Carreira, Éditeur scientifique ; Hisashi Yamamoto, Éditeur scientifique ; Johann H. Mulzer, Éditeur scientifique |
Editeur : |
Amsterdam : Elsevier |
Année de publication : |
2012 |
Collection : |
Comprehensive Chirality  |
Importance : |
xxiii, 782 p. |
Format : |
28 cm |
ISBN/ISSN/EAN : |
978-0-08-095167-6 |
Langues : |
Anglais (eng) |
Note de contenu : |
"* Introductory remarks: Chiral pool syntheses and diastereoselective reactions
* General principles of diastereoselective reactions: Rigid templates
* General principles of diastereoselective reactions: Diastereoselectivity via substrate-directable reactions (internal delivery) and heterocyclizations
* General principles of diastereoselective reactions: Acyclic control of diastereoselectivity
* General principles of diastereoselective reactions: Diastereoselective domino reactions
* Chiral pool synthesis: From ?-amino acids and derivatives
* Chiral pool synthesis: Starting from terpenes
* Chiral pool synthesis: Chiral pool syntheses starting from carbohydrates
* Chiral pool synthesis: Chiral pool syntheses from cis-cyclohexadiene diols
* Chiral pool synthesis: Chiral pool synthesis from hydroxy acids: Lactic acid, tartaric acid, malic acid, and 2-methyl-3-hydroxypropionic acid
* Chiral pool synthesis: Chiral pool synthesis from quinic acid
* Selected diastereoselective reactions: Additions of achiral carbanions to chiral aldehydes and ketones
* Selected diastereoselective reactions: Aldoltype additions
* Selected diastereoselective reactions: Enolate alkylation
* Selected diastereoselective reactions: Substrate controlled stereoselective conjugate addition reactions with organocopper reagents
* Selected diastereoselective reactions: Free radical additions and cyclizations
* Selected diastereoselective reactions: Intramolecular diels–alder reactions
* Selected diastereoselective reactions: diastereoselective intra- and intermolecular 1,3-dipolar cycloadditions in natural product synthesis
* Selected diastereoselective reactions: Electrocyclizations
* Selected diastereoselective reactions: Ionic and zwitterionic cyclizations
* Selected diastereoselective reactions: Diastereoface-differentiating claisen, cope, and [2,3]-wittig rearrangements in contemporary natural product synthesis
* Selected diastereoselective reactions: Heck type cyclizations
* Selected diastereoselective reactions: Gold catalyzed cyclizations
* Selected diastereoselective reactions: C–H insertions." |
Cote : |
EXCLU (SdL) |
Num_Inv : |
3291 |
Comprehensive Chirality. Vol.2 : Synthetic methods I – Chiral pool and diastereoselective methods [texte imprimé] / Erick M. Carreira, Éditeur scientifique ; Hisashi Yamamoto, Éditeur scientifique ; Johann H. Mulzer, Éditeur scientifique . - Amsterdam : Elsevier, 2012 . - xxiii, 782 p. ; 28 cm. - ( Comprehensive Chirality) . ISBN : 978-0-08-095167-6 Langues : Anglais ( eng)
Note de contenu : |
"* Introductory remarks: Chiral pool syntheses and diastereoselective reactions
* General principles of diastereoselective reactions: Rigid templates
* General principles of diastereoselective reactions: Diastereoselectivity via substrate-directable reactions (internal delivery) and heterocyclizations
* General principles of diastereoselective reactions: Acyclic control of diastereoselectivity
* General principles of diastereoselective reactions: Diastereoselective domino reactions
* Chiral pool synthesis: From ?-amino acids and derivatives
* Chiral pool synthesis: Starting from terpenes
* Chiral pool synthesis: Chiral pool syntheses starting from carbohydrates
* Chiral pool synthesis: Chiral pool syntheses from cis-cyclohexadiene diols
* Chiral pool synthesis: Chiral pool synthesis from hydroxy acids: Lactic acid, tartaric acid, malic acid, and 2-methyl-3-hydroxypropionic acid
* Chiral pool synthesis: Chiral pool synthesis from quinic acid
* Selected diastereoselective reactions: Additions of achiral carbanions to chiral aldehydes and ketones
* Selected diastereoselective reactions: Aldoltype additions
* Selected diastereoselective reactions: Enolate alkylation
* Selected diastereoselective reactions: Substrate controlled stereoselective conjugate addition reactions with organocopper reagents
* Selected diastereoselective reactions: Free radical additions and cyclizations
* Selected diastereoselective reactions: Intramolecular diels–alder reactions
* Selected diastereoselective reactions: diastereoselective intra- and intermolecular 1,3-dipolar cycloadditions in natural product synthesis
* Selected diastereoselective reactions: Electrocyclizations
* Selected diastereoselective reactions: Ionic and zwitterionic cyclizations
* Selected diastereoselective reactions: Diastereoface-differentiating claisen, cope, and [2,3]-wittig rearrangements in contemporary natural product synthesis
* Selected diastereoselective reactions: Heck type cyclizations
* Selected diastereoselective reactions: Gold catalyzed cyclizations
* Selected diastereoselective reactions: C–H insertions." |
Cote : |
EXCLU (SdL) |
Num_Inv : |
3291 |
|  |
Exemplaires(1)
3291
|
EXCLU |
Texte imprimé |
Salle de lecture |
Encyclopédie
|
Consultation sur place Exclu du prêt |

Titre de série : |
Comprehensive Chirality |
Titre : |
Vol.3 : Synthetic methods II – Chiral auxiliaries |
Type de document : |
texte imprimé |
Auteurs : |
Erick M. Carreira, Éditeur scientifique ; Hisashi Yamamoto, Éditeur scientifique ; Robert K. Boeckman Jr., Éditeur scientifique |
Editeur : |
Amsterdam : Elsevier |
Année de publication : |
2012 |
Collection : |
Comprehensive Chirality  |
Importance : |
xxvi, 859 p. |
Format : |
28 cm |
ISBN/ISSN/EAN : |
978-0-08-095167-6 |
Langues : |
Anglais (eng) |
Note de contenu : |
"* Amino acid derived auxiliaries: Amino acids as chiral auxiliaries
* Amino acid derived heterocyclic chiral auxiliaries: The use of oxazolidinones, oxazolidinethiones, thiazolidinethiones, and imidazolidinones
* Terpene derived auxiliaries: Camphor and pinene derived auxiliaries
* Terpene derived auxiliaries: Menthol and pulegone derived auxiliaries
* Terpene derived auxiliaries: Miscellaneous terpene derived auxiliaries
* Acetogenin (polypriopionate) derived auxiliaries: Tartaric acid
* Acetogenin (polypriopionate) derived auxillaries: Hydroxyacids
* Acetogenin (polypriopionate) derived auxillaries: Hydroxyacid derivatives
* Alkaloid derived auxiliaries: Cinchona alkaloids and derivatives
* Alkaloid-derived auxiliaries: Ephedra alkaloids
* Alkaloid derived auxiliaries: Miscellaneous alkaloids
* Carbohydrate derived auxiliaries: Mono (and disaccharide) derivatives
* Carbohydrate derived auxiliaries: Amino sugar and glycosylamine auxiliaries
* Synthetically derived chiral auxiliaries: Uses of derivatives of non-carbohydrate aldehydes and ketones in asymmetric synthesis
* Non-chiral pool derived synthetic auxiliaries: Use of C2 -symmetric chiral diols
* Synthetically derived auxiliaries: amines (including diamines), hydrazines and hydroxylamines, and amino alcohols
* Synthetically derived auxiliaries: Phosphorus derivatives
* Synthetically derived auxiliaries: Sulfur derivatives (including sulfilamines and sulfoximines)
* Synthetically derived auxiliaries: Organometallic derivatives (main group and transition metals)
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for lithium
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for magnesium and calcium
* Chiral ligation for boron and aluminum in stoichiometric asymmetric synthesis
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for silicon
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for tin and stannanes
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for zinc
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for chromium
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for titanium and zirconium complexes." |
Cote : |
EXCLU (SdL) |
Num_Inv : |
3292 |
Comprehensive Chirality. Vol.3 : Synthetic methods II – Chiral auxiliaries [texte imprimé] / Erick M. Carreira, Éditeur scientifique ; Hisashi Yamamoto, Éditeur scientifique ; Robert K. Boeckman Jr., Éditeur scientifique . - Amsterdam : Elsevier, 2012 . - xxvi, 859 p. ; 28 cm. - ( Comprehensive Chirality) . ISBN : 978-0-08-095167-6 Langues : Anglais ( eng)
Note de contenu : |
"* Amino acid derived auxiliaries: Amino acids as chiral auxiliaries
* Amino acid derived heterocyclic chiral auxiliaries: The use of oxazolidinones, oxazolidinethiones, thiazolidinethiones, and imidazolidinones
* Terpene derived auxiliaries: Camphor and pinene derived auxiliaries
* Terpene derived auxiliaries: Menthol and pulegone derived auxiliaries
* Terpene derived auxiliaries: Miscellaneous terpene derived auxiliaries
* Acetogenin (polypriopionate) derived auxiliaries: Tartaric acid
* Acetogenin (polypriopionate) derived auxillaries: Hydroxyacids
* Acetogenin (polypriopionate) derived auxillaries: Hydroxyacid derivatives
* Alkaloid derived auxiliaries: Cinchona alkaloids and derivatives
* Alkaloid-derived auxiliaries: Ephedra alkaloids
* Alkaloid derived auxiliaries: Miscellaneous alkaloids
* Carbohydrate derived auxiliaries: Mono (and disaccharide) derivatives
* Carbohydrate derived auxiliaries: Amino sugar and glycosylamine auxiliaries
* Synthetically derived chiral auxiliaries: Uses of derivatives of non-carbohydrate aldehydes and ketones in asymmetric synthesis
* Non-chiral pool derived synthetic auxiliaries: Use of C2 -symmetric chiral diols
* Synthetically derived auxiliaries: amines (including diamines), hydrazines and hydroxylamines, and amino alcohols
* Synthetically derived auxiliaries: Phosphorus derivatives
* Synthetically derived auxiliaries: Sulfur derivatives (including sulfilamines and sulfoximines)
* Synthetically derived auxiliaries: Organometallic derivatives (main group and transition metals)
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for lithium
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for magnesium and calcium
* Chiral ligation for boron and aluminum in stoichiometric asymmetric synthesis
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for silicon
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for tin and stannanes
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for zinc
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for chromium
* Stoichiometric auxiliary ligands for metals and main group elements: Ligands for titanium and zirconium complexes." |
Cote : |
EXCLU (SdL) |
Num_Inv : |
3292 |
|  |
Exemplaires(1)
3292
|
EXCLU |
Texte imprimé |
Salle de lecture |
Encyclopédie
|
Consultation sur place Exclu du prêt |

Titre de série : |
Comprehensive Chirality |
Titre : |
Vol.4 : Synthetic methods III – Catalytic methods: C–C bond formation |
Type de document : |
texte imprimé |
Auteurs : |
Erick M. Carreira, Éditeur scientifique ; Hisashi Yamamoto, Éditeur scientifique ; Masakatsu Shibasaki, Éditeur scientifique |
Editeur : |
Amsterdam : Elsevier |
Année de publication : |
2012 |
Collection : |
Comprehensive Chirality  |
Importance : |
xxvi, 390 p. |
Format : |
28 cm |
ISBN/ISSN/EAN : |
978-0-08-095167-6 |
Langues : |
Anglais (eng) |
Note de contenu : |
"* Introduction: General concepts
* C–C bond-forming reactions via the Heck reaction
* C–C bond-forming reactions via cross-coupling
* C–C bond formation (metathesis)
* C–C bond formation by metal-catalyzed asymmetric allylic alkylation
* C–C bond formation (metal-catalyzed reductive aldol coupling)
* C–C bond formation (transition metal-catalyzed Michael)
* C–C bond formation (metal-carbene catalyzed)
* C–C bond formation using Lewis acids and silicon enolates
* Enantioselective aldol reactions catalyzed by chiral Lewis bases
* C–C bond-forming reactions via transmetallation using silyl enol ethers
* Direct C–C bond formation (Henry, aza-Henry)
* Direct C–C bond formation (Michael, aldol, and Mannich)
* Reactions using thioamide and allylic cyanide
* C–C bond formation
* Enantioselective cyanation of carbonyls and imines
* Asymmetric 1,2-addition of organometallics to carbonyl and imine groups
* C–C bond formation (1,2-alkenylation)
* To catalytic asymmetric 1,2-alkynylation
* Other C–C bond formations including Au." |
Cote : |
EXCLU (SdL) |
Num_Inv : |
3293 |
Comprehensive Chirality. Vol.4 : Synthetic methods III – Catalytic methods: C–C bond formation [texte imprimé] / Erick M. Carreira, Éditeur scientifique ; Hisashi Yamamoto, Éditeur scientifique ; Masakatsu Shibasaki, Éditeur scientifique . - Amsterdam : Elsevier, 2012 . - xxvi, 390 p. ; 28 cm. - ( Comprehensive Chirality) . ISBN : 978-0-08-095167-6 Langues : Anglais ( eng)
Note de contenu : |
"* Introduction: General concepts
* C–C bond-forming reactions via the Heck reaction
* C–C bond-forming reactions via cross-coupling
* C–C bond formation (metathesis)
* C–C bond formation by metal-catalyzed asymmetric allylic alkylation
* C–C bond formation (metal-catalyzed reductive aldol coupling)
* C–C bond formation (transition metal-catalyzed Michael)
* C–C bond formation (metal-carbene catalyzed)
* C–C bond formation using Lewis acids and silicon enolates
* Enantioselective aldol reactions catalyzed by chiral Lewis bases
* C–C bond-forming reactions via transmetallation using silyl enol ethers
* Direct C–C bond formation (Henry, aza-Henry)
* Direct C–C bond formation (Michael, aldol, and Mannich)
* Reactions using thioamide and allylic cyanide
* C–C bond formation
* Enantioselective cyanation of carbonyls and imines
* Asymmetric 1,2-addition of organometallics to carbonyl and imine groups
* C–C bond formation (1,2-alkenylation)
* To catalytic asymmetric 1,2-alkynylation
* Other C–C bond formations including Au." |
Cote : |
EXCLU (SdL) |
Num_Inv : |
3293 |
|  |
Exemplaires(1)
3293
|
EXCLU |
Texte imprimé |
Salle de lecture |
Encyclopédie
|
Consultation sur place Exclu du prêt |

Titre de série : |
Comprehensive Chirality |
Titre : |
Vol.5 : Synthetic methods IV – Asymmetric oxidation reduction, C–N |
Type de document : |
texte imprimé |
Auteurs : |
Erick M. Carreira, Éditeur scientifique ; Hisashi Yamamoto, Éditeur scientifique ; Keiji Maruoka, Éditeur scientifique |
Editeur : |
Amsterdam : Elsevier |
Année de publication : |
2012 |
Collection : |
Comprehensive Chirality  |
Importance : |
xxvi, 599 p. |
Format : |
28 cm |
ISBN/ISSN/EAN : |
978-0-08-095167-6 |
Langues : |
Anglais (eng) |
Note de contenu : |
"* Asymmetric Baeyer–Villiger oxidation
* Oxidation: C–O bond formation by C–H activation
* Oxidation: Epoxidation (allylic alcohol, homoallylic alcohol, simple C=C, electron deficient C=C)
* Oxidation: ?-hydroxylation of carbonyls
* Oxidation: C–N bond formation by oxidation: C–H bond activation
* Oxidation: C–N bond formation by oxidation (aziridines)
* Oxidation: C–N bond formation by oxidation: Dinitrogen addition to double bond (diamino)
* Asymmetric S–O bond formation by oxidation
* Oxidation: C–X bond formation (X=Halogen, S, Se)
* Reduction – hydrogenation: C=C; chemoselective
* Reduction – hydrogenation: C=O; chemoselective
* Asymmetric hydrogenation of prochiral C=N bonds
* Reduction: Hydrosilylation
* Reduction: Hydroformylation C–H and C–C
* Reduction: Hydrocyanation of C=C
* Reduction: Enantioselective hydrovinylation of alkenes
* Reduction: Pinacol coupling
* Addition reaction: Kinetic resolution
* Addition reaction: 1,4 addition heteroatom
* Addition reaction: Cycloaddition involving oxidation (N=N, N=O; No C–C bond formed)
* Desymmetrization of meso diols
* Desymmetrization of meso epoxide
* Desymmetrization of meso anhydride." |
Cote : |
EXCLU (SdL) |
Num_Inv : |
3294 |
Comprehensive Chirality. Vol.5 : Synthetic methods IV – Asymmetric oxidation reduction, C–N [texte imprimé] / Erick M. Carreira, Éditeur scientifique ; Hisashi Yamamoto, Éditeur scientifique ; Keiji Maruoka, Éditeur scientifique . - Amsterdam : Elsevier, 2012 . - xxvi, 599 p. ; 28 cm. - ( Comprehensive Chirality) . ISBN : 978-0-08-095167-6 Langues : Anglais ( eng)
Note de contenu : |
"* Asymmetric Baeyer–Villiger oxidation
* Oxidation: C–O bond formation by C–H activation
* Oxidation: Epoxidation (allylic alcohol, homoallylic alcohol, simple C=C, electron deficient C=C)
* Oxidation: ?-hydroxylation of carbonyls
* Oxidation: C–N bond formation by oxidation: C–H bond activation
* Oxidation: C–N bond formation by oxidation (aziridines)
* Oxidation: C–N bond formation by oxidation: Dinitrogen addition to double bond (diamino)
* Asymmetric S–O bond formation by oxidation
* Oxidation: C–X bond formation (X=Halogen, S, Se)
* Reduction – hydrogenation: C=C; chemoselective
* Reduction – hydrogenation: C=O; chemoselective
* Asymmetric hydrogenation of prochiral C=N bonds
* Reduction: Hydrosilylation
* Reduction: Hydroformylation C–H and C–C
* Reduction: Hydrocyanation of C=C
* Reduction: Enantioselective hydrovinylation of alkenes
* Reduction: Pinacol coupling
* Addition reaction: Kinetic resolution
* Addition reaction: 1,4 addition heteroatom
* Addition reaction: Cycloaddition involving oxidation (N=N, N=O; No C–C bond formed)
* Desymmetrization of meso diols
* Desymmetrization of meso epoxide
* Desymmetrization of meso anhydride." |
Cote : |
EXCLU (SdL) |
Num_Inv : |
3294 |
|  |
Exemplaires(1)
3294
|
EXCLU |
Texte imprimé |
Salle de lecture |
Encyclopédie
|
Consultation sur place Exclu du prêt |

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