Bifunctional N-Heterocyclic-Carbene (NHC) Ligands in Metal-Catalyzed C-H Bond Functionalization / Jompol Thonpaen  

Public ISBD Titre : Bifunctional N-Heterocyclic-Carbene (NHC) Ligands in Metal-Catalyzed C-H Bond Functionalization Type de document : texte imprimé Auteurs : Jompol Thonpaen, Auteur ; Oliver Baslé, Directeur de thèse ; Marc Mauduit, Directeur de thèse Langues : Anglais (eng) Tags : C-H ACTIVATION  NHC Résumé : "The direct functionalization of inert CH bonds has emerged over the past two decades as an increasingly important synthetic tool. In particular, transition metal (TM)-catalyzed C-H functionalization has witnessed continuing improvements in performance, allowing expansion of the toolbox available for organic material synthesis, natural products synthesis, and drug-discovery programs. In spite of this success, there is still a need for the development of methodologies to efficiently enable C-H bond transformation under mild conditions. During the past two decades, N-heterocyclic carbenes (NHCs) have become ubiquitous ligands in coordination chemistry and catalysis. Their unique properties, including strong ?- donation, are responsible for forming robust TM catalysts that allow for the development of more efficient synthetic procedures. Nevertheless, the use of NHC ligands in transition metal-catalyzed C-H functionalization has remained limited. Because organoboron compounds are versatile intermediates in synthetic chemistry, the development of new catalytic systems for selective borylation of unactivated C-H bonds would afford new perspectives in organometallic and catalysis. Herein, this Thesis discloses an efficient and straightforward strategy to access various types of transition metal complexes bearing bidentate NHC-carboxylate ligands which were fully characterized including solid-state structures. These unprecedented complexes possessing chelating-NHC ligands exhibited high efficiency and selectivity in site selective borylation of inert C-H bonds under mild conditions including a photosensitizer-free photocatalytic conditions." Document : Thèse de Doctorat Etablissement_delivrance : Rennes, Ecole nationale supérieure de chimie Date_soutenance : 07/11/2019 Ecole_doctorale : Matière, Molécules Matériaux et Géosciences (Le Mans) Domaine : Chimie En ligne : http://www.theses.fr/2019ENCR0059 Bifunctional N-Heterocyclic-Carbene (NHC) Ligands in Metal-Catalyzed C-H Bond Functionalization [texte imprimé] / Jompol Thonpaen, Auteur ; Oliver Baslé, Directeur de thèse ; Marc Mauduit, Directeur de thèse . - [s.d.]. Langues : Anglais (eng) Tags : C-H ACTIVATION  NHC Résumé : "The direct functionalization of inert CH bonds has emerged over the past two decades as an increasingly important synthetic tool. In particular, transition metal (TM)-catalyzed C-H functionalization has witnessed continuing improvements in performance, allowing expansion of the toolbox available for organic material synthesis, natural products synthesis, and drug-discovery programs. In spite of this success, there is still a need for the development of methodologies to efficiently enable C-H bond transformation under mild conditions. During the past two decades, N-heterocyclic carbenes (NHCs) have become ubiquitous ligands in coordination chemistry and catalysis. Their unique properties, including strong ?- donation, are responsible for forming robust TM catalysts that allow for the development of more efficient synthetic procedures. Nevertheless, the use of NHC ligands in transition metal-catalyzed C-H functionalization has remained limited. Because organoboron compounds are versatile intermediates in synthetic chemistry, the development of new catalytic systems for selective borylation of unactivated C-H bonds would afford new perspectives in organometallic and catalysis. Herein, this Thesis discloses an efficient and straightforward strategy to access various types of transition metal complexes bearing bidentate NHC-carboxylate ligands which were fully characterized including solid-state structures. These unprecedented complexes possessing chelating-NHC ligands exhibited high efficiency and selectivity in site selective borylation of inert C-H bonds under mild conditions including a photosensitizer-free photocatalytic conditions." Document : Thèse de Doctorat Etablissement_delivrance : Rennes, Ecole nationale supérieure de chimie Date_soutenance : 07/11/2019 Ecole_doctorale : Matière, Molécules Matériaux et Géosciences (Le Mans) Domaine : Chimie En ligne : http://www.theses.fr/2019ENCR0059

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