Titre :	Dendrimer based nanocarriers for transcutaneous drug delivery
Type de document :	texte imprimé
Auteurs :	Venkata Vamsi Krishna Venuganti
Editeur :	Cambridge : ProQuest, Umi Dissertation Publishing
Année de publication :	2011
Importance :	254 p.
Format :	25 cm
ISBN/ISSN/EAN :	978-1-243-85210-6
Langues :	Anglais (eng)
Tags :	MOLECULAR BIOLOGY  PHARMACOLOGY  PHARMACEUTICAL SCIENCE
Index. décimale :	EQ -Equipe-
Résumé :	"This dissertation focuses on exploring the use of dendrimer as a novel nanocarrier for transcutaneous delivery of small and large drug molecules. To this end, the main objective was to understand structure-permeability relationship and use this knowledge to design dendrimer based transcutaneous drug delivery systems. Results from in-vitro skin penetration studies showed that poly (amidoamine) (PAMAM) dendrimer increased the skin penetration of 5FU by two to three fold when delivered from lipophilic vehicles. Skin pre-treatment with dendrimer enhanced the 5FU skin penetration greater than co-treatment, indicating that dendrimer enhances penetration mainly by interacting with skin[...]"
Cote :	LCC/M
Num_Inv :	3188
En ligne :	http://gradworks.umi.com/34/20/3420896.html

Dendrimer based nanocarriers for transcutaneous drug delivery [texte imprimé] / Venkata Vamsi Krishna Venuganti . - Cambridge : ProQuest, Umi Dissertation Publishing, 2011 . - 254 p. ; 25 cm.
ISBN : 978-1-243-85210-6
Langues : Anglais (eng)

Tags :	MOLECULAR BIOLOGY  PHARMACOLOGY  PHARMACEUTICAL SCIENCE
Index. décimale :	EQ -Equipe-
Résumé :	"This dissertation focuses on exploring the use of dendrimer as a novel nanocarrier for transcutaneous delivery of small and large drug molecules. To this end, the main objective was to understand structure-permeability relationship and use this knowledge to design dendrimer based transcutaneous drug delivery systems. Results from in-vitro skin penetration studies showed that poly (amidoamine) (PAMAM) dendrimer increased the skin penetration of 5FU by two to three fold when delivered from lipophilic vehicles. Skin pre-treatment with dendrimer enhanced the 5FU skin penetration greater than co-treatment, indicating that dendrimer enhances penetration mainly by interacting with skin[...]"
Cote :	LCC/M
Num_Inv :	3188
En ligne :	http://gradworks.umi.com/34/20/3420896.html