Dendrimer based nanocarriers for transcutaneous drug delivery / Venkata Vamsi Krishna Venuganti  

Public ISBD Titre : Dendrimer based nanocarriers for transcutaneous drug delivery Type de document : texte imprimé Auteurs : Venkata Vamsi Krishna Venuganti Editeur : Cambridge : ProQuest, Umi Dissertation Publishing Année de publication : 2011 Importance : 254 p. Format : 25 cm ISBN/ISSN/EAN : 978-1-243-85210-6 Langues : Anglais (eng) Tags : MOLECULAR BIOLOGY  PHARMACOLOGY  PHARMACEUTICAL SCIENCE Index. décimale : EQ -Equipe- Résumé : "This dissertation focuses on exploring the use of dendrimer as a novel nanocarrier for transcutaneous delivery of small and large drug molecules. To this end, the main objective was to understand structure-permeability relationship and use this knowledge to design dendrimer based transcutaneous drug delivery systems. Results from in-vitro skin penetration studies showed that poly (amidoamine) (PAMAM) dendrimer increased the skin penetration of 5FU by two to three fold when delivered from lipophilic vehicles. Skin pre-treatment with dendrimer enhanced the 5FU skin penetration greater than co-treatment, indicating that dendrimer enhances penetration mainly by interacting with skin[...]" Cote : LCC/M Num_Inv : 3188 En ligne : http://gradworks.umi.com/34/20/3420896.html Dendrimer based nanocarriers for transcutaneous drug delivery [texte imprimé] / Venkata Vamsi Krishna Venuganti . - Cambridge : ProQuest, Umi Dissertation Publishing, 2011 . - 254 p. ; 25 cm. ISBN : 978-1-243-85210-6 Langues : Anglais (eng) Tags : MOLECULAR BIOLOGY  PHARMACOLOGY  PHARMACEUTICAL SCIENCE Index. décimale : EQ -Equipe- Résumé : "This dissertation focuses on exploring the use of dendrimer as a novel nanocarrier for transcutaneous delivery of small and large drug molecules. To this end, the main objective was to understand structure-permeability relationship and use this knowledge to design dendrimer based transcutaneous drug delivery systems. Results from in-vitro skin penetration studies showed that poly (amidoamine) (PAMAM) dendrimer increased the skin penetration of 5FU by two to three fold when delivered from lipophilic vehicles. Skin pre-treatment with dendrimer enhanced the 5FU skin penetration greater than co-treatment, indicating that dendrimer enhances penetration mainly by interacting with skin[...]" Cote : LCC/M Num_Inv : 3188 En ligne : http://gradworks.umi.com/34/20/3420896.html

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