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Titre : Une nouvelle famille de macromolécules phosphorées : les dendrimères Titre original : A new family of phosphorus macromolecules : the dendrimers Type de document : texte imprimé Auteurs : Launay, Nathalie, Auteur ; Jean-Pierre Majoral, Directeur de thèse Année de publication : 1995 Langues : Français (fre) Tags : MACROMOLÉCULES PHOSPHORE-COMPOSÉS COMPOSES MACROCYCLIQUES
MACROMOLECULES PHOSPHORUS COMPOUNDS MACROCYCLIC COMPOUNDSRésumé : "Le mémoire se rapporte essentiellement à l'étude d'une nouvelle famille de macromolécules : les dendrimères. Ces molécules arborescentes ont l'avantage, par rapport aux polymères usuels, de présenter une structure monodisperse et bien définie, grâce au greffage contrôlé des molécules monomères étape par étape autour d'un cur plurifonctionnel. Ainsi, le premier chapitre est consacré à une mise au point bibliographique sur les dendrimères, au cours de laquelle est définie plus amplement ce nouvel objet de la chimie supramoléculaire, puis sont présentés les grands principes de synthèse en les illustrant de quelques exemples représentatifs, les méthodes de caractérisation et enfin les différentes applications potentielles. La présentation du travail personnel est repartie sur quatre chapitres. Lors du deuxième chapitre, nous exposons les premiers travaux que nous avons réalisés au laboratoire : il s'agit de la synthèse de plus petites architectures moléculaires : de nouveaux macrocycles phosphores et silicies. Ce n'est qu'au cours du troisième chapitre que nous abordons véritablement la mise au point de la synthèse de différentes familles de dendrimères phosphores. L'élaboration de dendrimères grâce à la réitération d'une séquence réactionnelle mettant en jeu successivement le sel de sodium du 4-hydroxybenzaldehyde et le sulfure de dichlorophosphomonohydrazide s'est révélée la méthode la plus performante : elle nous donne l'accès, à partir du cur trichlorothiophosphoryle, aux premiers dendrimères phosphores neutres jusqu'à la douzième génération. La réactivité des fonctions terminales de type aldéhyde ou chlore de cette famille de dendrimères est étudiée dans le quatrième chapitre. Elle aboutit à la synthèse d'autres familles de dendrimères phosphores possédant des fonctionnalisations organiques très variées, et en particulier aux premiers dendrimères plurifonctionnalisés qui comportent à chaque extrémité deux voire trois fonctions de natures différentes."
"The thesis essentially relates to the study of a new family of macromolecules: dendrimers. These tree-like molecules have the advantage, compared to usual polymers, of presenting a monodisperse and well-defined structure, thanks to the controlled grafting of monomer molecules step by step around a multifunctional core. Thus, the first chapter is devoted to a bibliographical update on dendrimers, during which this new object of supramolecular chemistry is more fully defined, then the main principles of synthesis are presented by illustrating them with some representative examples, the characterization methods and finally the various potential applications. The presentation of personal work is spread over four chapters. In the second chapter, we present the first work that we carried out in the laboratory: it concerns the synthesis of smaller molecular architectures: new phosphorus and silicia macrocycles. It is only during the third chapter that we truly approach the development of the synthesis of different families of phosphorus dendrimers. The development of dendrimers by repeating a reaction sequence successively involving the sodium salt of 4-hydroxybenzaldehyde and dichlorophosphomonohydrazide sulfide has proven to be the most effective method: it gives us access, starting with the trichlorothiophosphoryl core, to the first neutral phosphorus dendrimers up to the twelfth generation. The reactivity of the terminal functions of the aldehyde or chlorine type of this family of dendrimers is studied in the fourth chapter. It leads to the synthesis of other families of phosphorus dendrimers with very varied organic functionalizations, and in particular to the first multifunctionalized dendrimers which have two or even three functions of different natures at each end."
Document : Thèse de Doctorat Etablissement_delivrance : Université de Toulouse 3 Date_soutenance : 21/06/1995 Ecole_doctorale : Sciences de la Matière Domaine : Chimie Moléculaire et Supramoléculaire Localisation : LCC En ligne : https://theses.fr/1995TOU30102 Une nouvelle famille de macromolécules phosphorées : les dendrimères = A new family of phosphorus macromolecules : the dendrimers [texte imprimé] / Launay, Nathalie, Auteur ; Jean-Pierre Majoral, Directeur de thèse . - 1995.
Langues : Français (fre)
Tags : MACROMOLÉCULES PHOSPHORE-COMPOSÉS COMPOSES MACROCYCLIQUES
MACROMOLECULES PHOSPHORUS COMPOUNDS MACROCYCLIC COMPOUNDSRésumé : "Le mémoire se rapporte essentiellement à l'étude d'une nouvelle famille de macromolécules : les dendrimères. Ces molécules arborescentes ont l'avantage, par rapport aux polymères usuels, de présenter une structure monodisperse et bien définie, grâce au greffage contrôlé des molécules monomères étape par étape autour d'un cur plurifonctionnel. Ainsi, le premier chapitre est consacré à une mise au point bibliographique sur les dendrimères, au cours de laquelle est définie plus amplement ce nouvel objet de la chimie supramoléculaire, puis sont présentés les grands principes de synthèse en les illustrant de quelques exemples représentatifs, les méthodes de caractérisation et enfin les différentes applications potentielles. La présentation du travail personnel est repartie sur quatre chapitres. Lors du deuxième chapitre, nous exposons les premiers travaux que nous avons réalisés au laboratoire : il s'agit de la synthèse de plus petites architectures moléculaires : de nouveaux macrocycles phosphores et silicies. Ce n'est qu'au cours du troisième chapitre que nous abordons véritablement la mise au point de la synthèse de différentes familles de dendrimères phosphores. L'élaboration de dendrimères grâce à la réitération d'une séquence réactionnelle mettant en jeu successivement le sel de sodium du 4-hydroxybenzaldehyde et le sulfure de dichlorophosphomonohydrazide s'est révélée la méthode la plus performante : elle nous donne l'accès, à partir du cur trichlorothiophosphoryle, aux premiers dendrimères phosphores neutres jusqu'à la douzième génération. La réactivité des fonctions terminales de type aldéhyde ou chlore de cette famille de dendrimères est étudiée dans le quatrième chapitre. Elle aboutit à la synthèse d'autres familles de dendrimères phosphores possédant des fonctionnalisations organiques très variées, et en particulier aux premiers dendrimères plurifonctionnalisés qui comportent à chaque extrémité deux voire trois fonctions de natures différentes."
"The thesis essentially relates to the study of a new family of macromolecules: dendrimers. These tree-like molecules have the advantage, compared to usual polymers, of presenting a monodisperse and well-defined structure, thanks to the controlled grafting of monomer molecules step by step around a multifunctional core. Thus, the first chapter is devoted to a bibliographical update on dendrimers, during which this new object of supramolecular chemistry is more fully defined, then the main principles of synthesis are presented by illustrating them with some representative examples, the characterization methods and finally the various potential applications. The presentation of personal work is spread over four chapters. In the second chapter, we present the first work that we carried out in the laboratory: it concerns the synthesis of smaller molecular architectures: new phosphorus and silicia macrocycles. It is only during the third chapter that we truly approach the development of the synthesis of different families of phosphorus dendrimers. The development of dendrimers by repeating a reaction sequence successively involving the sodium salt of 4-hydroxybenzaldehyde and dichlorophosphomonohydrazide sulfide has proven to be the most effective method: it gives us access, starting with the trichlorothiophosphoryl core, to the first neutral phosphorus dendrimers up to the twelfth generation. The reactivity of the terminal functions of the aldehyde or chlorine type of this family of dendrimers is studied in the fourth chapter. It leads to the synthesis of other families of phosphorus dendrimers with very varied organic functionalizations, and in particular to the first multifunctionalized dendrimers which have two or even three functions of different natures at each end."
Document : Thèse de Doctorat Etablissement_delivrance : Université de Toulouse 3 Date_soutenance : 21/06/1995 Ecole_doctorale : Sciences de la Matière Domaine : Chimie Moléculaire et Supramoléculaire Localisation : LCC En ligne : https://theses.fr/1995TOU30102
Titre : Calixarenes Type de document : texte imprimé Auteurs : C. David Gutsche, Auteur Editeur : Cambridge : Royal Society of Chemistry Collection : Monographs in supramolecular chemistry, ISSN 1368-8642 num. 1 Importance : xii, 223 p. ISBN/ISSN/EAN : 978-0-85186-916-2 Langues : Anglais (eng) Tags : MACROMOLECULES Index. décimale : EQ -Equipe- Résumé : "The aim of this volume is to provide researchers with a complete survey of the chemistry of the molecular baskets called calixarenes. Historical vignettes and biographies of those responsible for early research in the field have been included in the text." Note de contenu : "1- From resinous tar to molecular baskets: the resinous tar- glistening crystals- the Zinke products- more crystals - the Niederl products- cyclic tetramers-proofs of structure- the petrolite chapter- cyclic tetramers and the quest for enzyme mimics- unraveling the literature- nomenclature of the calixarenes.2- Making the baskets - synthesis of calixarenes: procedures for one-step base-induced syntheses- procedures for one-step acid-catalyzed synthesis of calixarenes- procedures for one-step formation of calixarenes under neutral conditions- multi-step synthesis of calixarenes- mechanisms of calixarene-forming reactions- homocalixarenes, oxacalixarenes and homooxacalixarenes- heterocalixarenes. 3- Proving the baskets -the characterization and properties of calixarenes: x-ray crystallography -the ultimate proof of structure- proof of structure by chemical interconversion- physical properties of calixarenes- spectral properties of calixarenes- TLC and HPLC analysis of calixarenes4- Shaping the baskets - conformations of calixarenes: conformations of flexible calixarenes in the solid state- conformations of flexible calixarenes in solution-- resorcinol-derived calixarenes-conformations of non-hydroxylic calixarenes- conformationally immobile calixarenes-the conformations of calixarene oxyanions. 5- Embroidering the baskets-reactions of calixarenes and introduction of functional groups: reactions at the "lower rim" of the calix- reactions at the "upper rim" of the calix-- oxidation reactions of calixarenes. 6- Filling the baskets - complex formation with calixarenes: solid state complexes- solution state complexes in nonaqueous solvents- solution state complexes of water-soluble calixarenes.7- Using the baskets - calixarenes in action: the patent literature of calixarenes-calixarenes in industry-calixarenes as complexers of neutral compounds-calixarenes as catalysts and biomimics-calixarenes as physiological compounds." Cote : LCC/M Num_Inv : 622 Calixarenes [texte imprimé] / C. David Gutsche, Auteur . - Cambridge : Royal Society of Chemistry, [s.d.] . - xii, 223 p.. - (Monographs in supramolecular chemistry, ISSN 1368-8642; 1) .
ISBN : 978-0-85186-916-2
Langues : Anglais (eng)
Tags : MACROMOLECULES Index. décimale : EQ -Equipe- Résumé : "The aim of this volume is to provide researchers with a complete survey of the chemistry of the molecular baskets called calixarenes. Historical vignettes and biographies of those responsible for early research in the field have been included in the text." Note de contenu : "1- From resinous tar to molecular baskets: the resinous tar- glistening crystals- the Zinke products- more crystals - the Niederl products- cyclic tetramers-proofs of structure- the petrolite chapter- cyclic tetramers and the quest for enzyme mimics- unraveling the literature- nomenclature of the calixarenes.2- Making the baskets - synthesis of calixarenes: procedures for one-step base-induced syntheses- procedures for one-step acid-catalyzed synthesis of calixarenes- procedures for one-step formation of calixarenes under neutral conditions- multi-step synthesis of calixarenes- mechanisms of calixarene-forming reactions- homocalixarenes, oxacalixarenes and homooxacalixarenes- heterocalixarenes. 3- Proving the baskets -the characterization and properties of calixarenes: x-ray crystallography -the ultimate proof of structure- proof of structure by chemical interconversion- physical properties of calixarenes- spectral properties of calixarenes- TLC and HPLC analysis of calixarenes4- Shaping the baskets - conformations of calixarenes: conformations of flexible calixarenes in the solid state- conformations of flexible calixarenes in solution-- resorcinol-derived calixarenes-conformations of non-hydroxylic calixarenes- conformationally immobile calixarenes-the conformations of calixarene oxyanions. 5- Embroidering the baskets-reactions of calixarenes and introduction of functional groups: reactions at the "lower rim" of the calix- reactions at the "upper rim" of the calix-- oxidation reactions of calixarenes. 6- Filling the baskets - complex formation with calixarenes: solid state complexes- solution state complexes in nonaqueous solvents- solution state complexes of water-soluble calixarenes.7- Using the baskets - calixarenes in action: the patent literature of calixarenes-calixarenes in industry-calixarenes as complexers of neutral compounds-calixarenes as catalysts and biomimics-calixarenes as physiological compounds." Cote : LCC/M Num_Inv : 622 Exemplaires(1)
Code-barres Cote Support Localisation Section Disponibilité 622 LCC/M Texte imprimé Equipe Livre Equipe - Demande préalable
DisponibleComplex macromolecular architectures: Synthesis, characterization, and self-assembly / Nikos Hadjichristidis
Titre : Complex macromolecular architectures: Synthesis, characterization, and self-assembly Type de document : texte imprimé Auteurs : Nikos Hadjichristidis, Éditeur scientifique ; Akira Hirao, Éditeur scientifique ; Yasuyuki Tezuka, Éditeur scientifique ; Filip Du Prez, Éditeur scientifique Editeur : Singapore : John Wiley & Sons Année de publication : 2011 Importance : xxiii, 832 p. ISBN/ISSN/EAN : 978-0-470-82513-6 Langues : Anglais (eng) Catégories : Matériaux Tags : MACROMOLECULES POLYMERIZATION Index. décimale : B-G Résumé : "The field of CMA (complex macromolecular architecture) stands at the cutting edge of materials science, and has been a locus of intense research activity in recent years. This book gives an extensive description of the synthesis, characterization, and self-assembly of recently-developed advanced architectural materials with a number of potential applications.
The architectural polymers, including bio-conjugated hybrid polymers with poly(amino acid)s and gluco-polymers, star-branched and dendrimer-like hyperbranched polymers, cyclic polymers, dendrigraft polymers, rod-coil and helix-coil block copolymers, are introduced chapter by chapter in the book. In particular, the book also emphasizes the topic of synthetic breakthroughs by living/controlled polymerization since 2000."Cote : B-G040 (SdS) Num_Inv : 3394 Complex macromolecular architectures: Synthesis, characterization, and self-assembly [texte imprimé] / Nikos Hadjichristidis, Éditeur scientifique ; Akira Hirao, Éditeur scientifique ; Yasuyuki Tezuka, Éditeur scientifique ; Filip Du Prez, Éditeur scientifique . - Singapore : John Wiley & Sons, 2011 . - xxiii, 832 p.
ISBN : 978-0-470-82513-6
Langues : Anglais (eng)
Catégories : Matériaux Tags : MACROMOLECULES POLYMERIZATION Index. décimale : B-G Résumé : "The field of CMA (complex macromolecular architecture) stands at the cutting edge of materials science, and has been a locus of intense research activity in recent years. This book gives an extensive description of the synthesis, characterization, and self-assembly of recently-developed advanced architectural materials with a number of potential applications.
The architectural polymers, including bio-conjugated hybrid polymers with poly(amino acid)s and gluco-polymers, star-branched and dendrimer-like hyperbranched polymers, cyclic polymers, dendrigraft polymers, rod-coil and helix-coil block copolymers, are introduced chapter by chapter in the book. In particular, the book also emphasizes the topic of synthetic breakthroughs by living/controlled polymerization since 2000."Cote : B-G040 (SdS) Num_Inv : 3394 Exemplaires(1)
Code-barres Cote Support Localisation Section Disponibilité 3394 B-G040 Texte imprimé Bibliothèque Livre Disponible
Titre : Macromolecular anticancer therapeutics Type de document : texte imprimé Auteurs : Harivardhan, L. Reddy, Éditeur scientifique ; Patrick Couvreur, Éditeur scientifique Editeur : New York : Springer Année de publication : 2010 Collection : Cancer Drug Discovery and Development, ISSN 2196-9906 Importance : xx, 623 p. Présentation : ill., graph. Darst. Format : 24 cm ISBN/ISSN/EAN : 978-1-4419-0506-2 Langues : Anglais (eng) Tags : CANCER CHEMOTHERAPY ANTICANCER THERAPEUTICS MACROMOLECULES Index. décimale : EQ -Equipe- Résumé : "The field of macromolecular therapeutics for cancer therapy is of considerable importance, as these therapeutic systems are gaining more and more interest to give new directions for the treatment of this dreadful disease. Macromolecular Anticancer Therapeutics, which describes in detail the macromolecular therapeutics for cancer therapy, covers the classification of these anticancer drugs based on therapeutic targets, and elaborates on different classes of anticancer therapeutics which are either in pre-clinic or in clinical phases or are already commercialized. This book also discusses various signal transduction pathways involved in the cancer growth and resistance to therapy, providing a clear insight into the molecular mechanistic aspects of this topic; it also describes the essential targets for efficient cancer therapy. In detail, this volume elaborates the different categories of macromolecular therapeutics of respectively natural and synthetic polymer and lipid origin, their chemistry, design and development, opportunities and challenges, current status, pre-clinic and clinical progresses. In addition, the design, development, and the challenges involved in future directions for cancer therapy using various categories of antibody-based therapeutics are elaborated in areas such as antibody-mediated drug targeting to cancer employing antibody-drug conjugates, radioimmunoconjugates, toxin-antibody conjugates, antibody-mediated enzyme pro-drug therapeutics, and also using antibodies alone to interfere with specific molecular targets responsible for tumor growth and progression. Besides the current status, pre-clinic and clinical progress of a variety of therapeutic anticancer oligonucleotides and siRNA designed and developed for specific inhibition of oncogenes are detailed. Furthermore, in this book, special attention is given to the treatment of breast cancer based on a comprehensive description about molecular mechanisms involved, hormone receptors implicated and molecular therapeutic interventions." Cote : LCC/M Num_Inv : 3118 Macromolecular anticancer therapeutics [texte imprimé] / Harivardhan, L. Reddy, Éditeur scientifique ; Patrick Couvreur, Éditeur scientifique . - New York : Springer, 2010 . - xx, 623 p. : ill., graph. Darst. ; 24 cm. - (Cancer Drug Discovery and Development, ISSN 2196-9906) .
ISBN : 978-1-4419-0506-2
Langues : Anglais (eng)
Tags : CANCER CHEMOTHERAPY ANTICANCER THERAPEUTICS MACROMOLECULES Index. décimale : EQ -Equipe- Résumé : "The field of macromolecular therapeutics for cancer therapy is of considerable importance, as these therapeutic systems are gaining more and more interest to give new directions for the treatment of this dreadful disease. Macromolecular Anticancer Therapeutics, which describes in detail the macromolecular therapeutics for cancer therapy, covers the classification of these anticancer drugs based on therapeutic targets, and elaborates on different classes of anticancer therapeutics which are either in pre-clinic or in clinical phases or are already commercialized. This book also discusses various signal transduction pathways involved in the cancer growth and resistance to therapy, providing a clear insight into the molecular mechanistic aspects of this topic; it also describes the essential targets for efficient cancer therapy. In detail, this volume elaborates the different categories of macromolecular therapeutics of respectively natural and synthetic polymer and lipid origin, their chemistry, design and development, opportunities and challenges, current status, pre-clinic and clinical progresses. In addition, the design, development, and the challenges involved in future directions for cancer therapy using various categories of antibody-based therapeutics are elaborated in areas such as antibody-mediated drug targeting to cancer employing antibody-drug conjugates, radioimmunoconjugates, toxin-antibody conjugates, antibody-mediated enzyme pro-drug therapeutics, and also using antibodies alone to interfere with specific molecular targets responsible for tumor growth and progression. Besides the current status, pre-clinic and clinical progress of a variety of therapeutic anticancer oligonucleotides and siRNA designed and developed for specific inhibition of oncogenes are detailed. Furthermore, in this book, special attention is given to the treatment of breast cancer based on a comprehensive description about molecular mechanisms involved, hormone receptors implicated and molecular therapeutic interventions." Cote : LCC/M Num_Inv : 3118 Exemplaires(1)
Code-barres Cote Support Localisation Section Disponibilité 3118 LCC/M Texte imprimé Equipe Livre Equipe - Demande préalable
Disponible