Cisplatin: Chemistry and biochemistry of a leading anticancer drug / Bernhard Lippert

Public ISBD Titre : Cisplatin: Chemistry and biochemistry of a leading anticancer drug Type de document : texte imprimé Auteurs : Bernhard Lippert, Éditeur scientifique Editeur : Zurich : Helvetica Chimica Acta Année de publication : 1999 Autre Editeur : Weinheim : Wiley-VCH Importance : xii, 563 p. Format : 25 cm ISBN/ISSN/EAN : 978-3-906390-20-8 Langues : Anglais (eng) Catégories : Biochimie Tags : CISPLATIN  CANCER CHEMOTHERAPY Index. décimale : B-F Résumé : "30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as * the chemistry and biochemistry of cisplatin, * the clinical status of Pt anticancer drugs, * the impact of cisplatin on inorganic and coordination chemistry, * new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis[...]." Cote : B-F030 (SdS) Num_Inv : 2441 Cisplatin: Chemistry and biochemistry of a leading anticancer drug [texte imprimé] / Bernhard Lippert, Éditeur scientifique . - Zurich : Helvetica Chimica Acta : Weinheim : Wiley-VCH, 1999 . - xii, 563 p. ; 25 cm. ISBN : 978-3-906390-20-8 Langues : Anglais (eng) Catégories : Biochimie Tags : CISPLATIN  CANCER CHEMOTHERAPY Index. décimale : B-F Résumé : "30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as * the chemistry and biochemistry of cisplatin, * the clinical status of Pt anticancer drugs, * the impact of cisplatin on inorganic and coordination chemistry, * new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis[...]." Cote : B-F030 (SdS) Num_Inv : 2441

Exemplaires(1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
2441	B-F030	Texte imprimé	Bibliothèque	Livre	Disponible

Computer-assisted lead finding and optimization: Current tools for medicinal chemistry / Han Van de Waterbeemd

Public ISBD Titre : Computer-assisted lead finding and optimization: Current tools for medicinal chemistry Type de document : texte imprimé Auteurs : Han Van de Waterbeemd, Éditeur scientifique ; Bernard Testa, Éditeur scientifique ; Gerd Folkers, Éditeur scientifique Editeur : Zurich : Helvetica Chimica Acta Année de publication : 1997 Autre Editeur : Weinheim : Wiley-VCH Importance : 553 p. ISBN/ISSN/EAN : 978-3-906390-16-1 Langues : Anglais (eng) Tags : COMPUTER-ASSISTED LEAD FINDING  MEDICINAL CHEMISTRY Index. décimale : EQ -Equipe- Résumé : "Computer-assisted techniques are well-integrated in modern drug discovery and used for the finding of new leads, the optimization of receptor or enzyme affinity, as well as of pharmacokinetic and physicochemical properties. In this book an account is found of current strategies used in computer-assisted drug design. Important topics include progress in chemometrics, molecular modeling and three-dimensional QSAR approaches. Relatively new mathematical methods such as genetic algorithms or artificial neural networks and fuzzy logic have found their application in rational molecular design. As is amply illustrated, based on recent developments in these disciplines, important progress has been made in lead finding strategies. This is of great importance to the pharmaceutical industry. Thus, all scientists investigating quantitative structure-activity relationships in their broadest sense, in medicinal, agricultural, or environmental chemistry will benefit from this book." Cote : LCC/K Num_Inv : 2418 Computer-assisted lead finding and optimization: Current tools for medicinal chemistry [texte imprimé] / Han Van de Waterbeemd, Éditeur scientifique ; Bernard Testa, Éditeur scientifique ; Gerd Folkers, Éditeur scientifique . - Zurich : Helvetica Chimica Acta : Weinheim : Wiley-VCH, 1997 . - 553 p. ISBN : 978-3-906390-16-1 Langues : Anglais (eng) Tags : COMPUTER-ASSISTED LEAD FINDING  MEDICINAL CHEMISTRY Index. décimale : EQ -Equipe- Résumé : "Computer-assisted techniques are well-integrated in modern drug discovery and used for the finding of new leads, the optimization of receptor or enzyme affinity, as well as of pharmacokinetic and physicochemical properties. In this book an account is found of current strategies used in computer-assisted drug design. Important topics include progress in chemometrics, molecular modeling and three-dimensional QSAR approaches. Relatively new mathematical methods such as genetic algorithms or artificial neural networks and fuzzy logic have found their application in rational molecular design. As is amply illustrated, based on recent developments in these disciplines, important progress has been made in lead finding strategies. This is of great importance to the pharmaceutical industry. Thus, all scientists investigating quantitative structure-activity relationships in their broadest sense, in medicinal, agricultural, or environmental chemistry will benefit from this book." Cote : LCC/K Num_Inv : 2418

Exemplaires(1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
2418	LCC/K	Texte imprimé	Equipe	Livre	Equipe - Demande préalable Disponible

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