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The biochemistry of drug metabolism, Volume 2. Conjugations, consequences of metabolism, influencing factors / Bernard Testa

Public ISBD Titre de série : The biochemistry of drug metabolism, Volume 2 Titre : Conjugations, consequences of metabolism, influencing factors Type de document : texte imprimé Auteurs : Bernard Testa ; Stefanie D. Kramer Editeur : Weinheim : Wiley-VCH Année de publication : 2010 Importance : xiii, 588 p. Présentation : ill. Format : 24 cm ISBN/ISSN/EAN : 978-3-906390-54-3 Langues : Anglais (eng) Catégories : Biochimie Tags : DRUGS  METABOLISM Index. décimale : B-F Résumé : "Volume Two contains the last four parts of this work. Part 4 is devoted to the huge field of conjugation reactions, with much information being given on transferases. As in the two preceding parts, each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials. The reactions examined here include methylation, sulfation, glucuronidation, acetylation, conjugation with glutathione, while there is also a rigorous presentation of the pivotal role of xenobiotic-coenzyme A conjugates as a crossroads to various metabolic reactions. The next part examines the consequences of drug and xenobiotic metabolism in a pharmacological and toxicological perspective, with due attention paid to full activation, as is found with prodrugs, and to the worrying case of xenobiotic toxification. Parts 6 and 7 cover the inter-individual and intra-individual factors that influence drug metabolism, starting with an introduction to evolutionary events leading to species differences in the metabolism of xenobiotics and to polymorphisms within a particular species. Focusing on humans, the most relevant polymorphic drug-metabolizing enzymes are discussed, concentrating on ethnic differences and on the consequences for the pharmacokinetic behavior of affected drugs, while also introducing sex-dependent metabolic reactions. The final part introduces the mechanisms leading to increases or decreases in enzyme activities as the concept of enzyme induction via nuclear receptors and the different mechanisms of enzyme inhibition are explained. With these basics in mind, various influencing factors are discussed, including physiological and pathological conditions, as well as drugs, nutrients and environmental agents with a special focus on drug-drug interactions." Cote : B-F034-2 (SdS) Num_Inv : 3061 The biochemistry of drug metabolism, Volume 2. Conjugations, consequences of metabolism, influencing factors [texte imprimé] / Bernard Testa ; Stefanie D. Kramer . - Weinheim : Wiley-VCH, 2010 . - xiii, 588 p. : ill. ; 24 cm. ISBN : 978-3-906390-54-3 Langues : Anglais (eng) Catégories : Biochimie Tags : DRUGS  METABOLISM Index. décimale : B-F Résumé : "Volume Two contains the last four parts of this work. Part 4 is devoted to the huge field of conjugation reactions, with much information being given on transferases. As in the two preceding parts, each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials. The reactions examined here include methylation, sulfation, glucuronidation, acetylation, conjugation with glutathione, while there is also a rigorous presentation of the pivotal role of xenobiotic-coenzyme A conjugates as a crossroads to various metabolic reactions. The next part examines the consequences of drug and xenobiotic metabolism in a pharmacological and toxicological perspective, with due attention paid to full activation, as is found with prodrugs, and to the worrying case of xenobiotic toxification. Parts 6 and 7 cover the inter-individual and intra-individual factors that influence drug metabolism, starting with an introduction to evolutionary events leading to species differences in the metabolism of xenobiotics and to polymorphisms within a particular species. Focusing on humans, the most relevant polymorphic drug-metabolizing enzymes are discussed, concentrating on ethnic differences and on the consequences for the pharmacokinetic behavior of affected drugs, while also introducing sex-dependent metabolic reactions. The final part introduces the mechanisms leading to increases or decreases in enzyme activities as the concept of enzyme induction via nuclear receptors and the different mechanisms of enzyme inhibition are explained. With these basics in mind, various influencing factors are discussed, including physiological and pathological conditions, as well as drugs, nutrients and environmental agents with a special focus on drug-drug interactions." Cote : B-F034-2 (SdS) Num_Inv : 3061

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Biochemistry : the chemical reactions of living cells / David E. Metzler

Public ISBD Titre : Biochemistry : the chemical reactions of living cells Type de document : texte imprimé Auteurs : David E. Metzler, Auteur Editeur : New-York : Academic Press Année de publication : 1977 Importance : xxxii, 1129 p. ISBN/ISSN/EAN : 978-0-12-492550-2 Langues : Anglais (eng) Catégories : Biochimie Tags : BIOCHEMISTRY  METABOLISM Note de contenu : "The scene of action; The molecules from which we are made; Energetics of biochemical reactions; How molecules stick together; Membranes and cell coats; Enzymes : the protein catalysts of cells; The kinds of reactions catalyzed by enzymes; Coenzymes : nature's special reagents; Organization of metabolism: catabolic pathways; How oxygen meets the electrons with generation of ATP, and other stories; Biosynthesis : how new molecules are put together; Some specific pathways of metabolism of carbohydrates and lipids; Light in biology; The metabolism of nitrogen-containing compounds; Biochemical genetics and the synthetis of nucleic acids and proteins; Growth, differentiation, and chemical communication between cells" Cote : B-F004 (SdS) Num_Inv : 364 Biochemistry : the chemical reactions of living cells [texte imprimé] / David E. Metzler, Auteur . - New-York : Academic Press, 1977 . - xxxii, 1129 p. ISBN : 978-0-12-492550-2 Langues : Anglais (eng) Catégories : Biochimie Tags : BIOCHEMISTRY  METABOLISM Note de contenu : "The scene of action; The molecules from which we are made; Energetics of biochemical reactions; How molecules stick together; Membranes and cell coats; Enzymes : the protein catalysts of cells; The kinds of reactions catalyzed by enzymes; Coenzymes : nature's special reagents; Organization of metabolism: catabolic pathways; How oxygen meets the electrons with generation of ATP, and other stories; Biosynthesis : how new molecules are put together; Some specific pathways of metabolism of carbohydrates and lipids; Light in biology; The metabolism of nitrogen-containing compounds; Biochemical genetics and the synthetis of nucleic acids and proteins; Growth, differentiation, and chemical communication between cells" Cote : B-F004 (SdS) Num_Inv : 364

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The biochemistry of drug metabolism, Volume 1. Principles, redox reactions, hydrolyses / Bernard Testa

Public ISBD Titre de série : The biochemistry of drug metabolism, Volume 1 Titre : Principles, redox reactions, hydrolyses Type de document : texte imprimé Auteurs : Bernard Testa ; Stefanie D. Kramer Editeur : Weinheim : Wiley-VCH Année de publication : 2008 Importance : xiii, 319 p. Présentation : ill. Format : 24 cm ISBN/ISSN/EAN : 978-3-906390-53-6 Langues : Anglais (eng) Catégories : Biochimie Tags : DRUGS  METABOLISM Index. décimale : B-F Résumé : "The first of the two volumes is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug metabolism in animals and humans. This is followed by an introduction to the all-important issue of the consequences of drug and xenobiotic metabolism, providing an initial overview of pharmacokinetic, pharmacological and toxicological consequences. The last chapter examines drug metabolism in the context of drug research, with a focus on medicinal chemistry. The second part is a major component of the book, corresponding to the role of oxidoreductases as major agents of metabolism. Cytochromes P450 receive particular attention, namely their multiplicity, structure, catalytic mechanisms, and the various reactions they catalyze, while other oxidoreductases are also presented, such as flavin monooxygenases, monoamine oxidases and other amine oxidases, aldehyde oxidase and xanthine dehydrogenase, peroxidases, and dehydrogenases-reductases. Each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials. Part Three begins with a survey of the classification, properties and catalytic mechanism of the innumerable hydrolases known or suspected to play a role in xenobiotic metabolism. The focus then shifts to a systematic presentation of the various substrate classes, namely carboxylic esters, amides and peptides, lactams and lactones, esters of inorganic acids, alkene and arene epoxides, and some miscellaneous hydrolyzable moieties." Cote : B-F034-1 (SdS) Num_Inv : 3060 The biochemistry of drug metabolism, Volume 1. Principles, redox reactions, hydrolyses [texte imprimé] / Bernard Testa ; Stefanie D. Kramer . - Weinheim : Wiley-VCH, 2008 . - xiii, 319 p. : ill. ; 24 cm. ISBN : 978-3-906390-53-6 Langues : Anglais (eng) Catégories : Biochimie Tags : DRUGS  METABOLISM Index. décimale : B-F Résumé : "The first of the two volumes is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug metabolism in animals and humans. This is followed by an introduction to the all-important issue of the consequences of drug and xenobiotic metabolism, providing an initial overview of pharmacokinetic, pharmacological and toxicological consequences. The last chapter examines drug metabolism in the context of drug research, with a focus on medicinal chemistry. The second part is a major component of the book, corresponding to the role of oxidoreductases as major agents of metabolism. Cytochromes P450 receive particular attention, namely their multiplicity, structure, catalytic mechanisms, and the various reactions they catalyze, while other oxidoreductases are also presented, such as flavin monooxygenases, monoamine oxidases and other amine oxidases, aldehyde oxidase and xanthine dehydrogenase, peroxidases, and dehydrogenases-reductases. Each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials. Part Three begins with a survey of the classification, properties and catalytic mechanism of the innumerable hydrolases known or suspected to play a role in xenobiotic metabolism. The focus then shifts to a systematic presentation of the various substrate classes, namely carboxylic esters, amides and peptides, lactams and lactones, esters of inorganic acids, alkene and arene epoxides, and some miscellaneous hydrolyzable moieties." Cote : B-F034-1 (SdS) Num_Inv : 3060

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