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The anticancer drugs / William B. Pratt
Titre : The anticancer drugs Type de document : texte imprimé Auteurs : William B. Pratt, Auteur ; Raymond W. Ruddon, Auteur ; William D. Ensminger, Auteur ; J. Maybaum, Auteur Mention d'édition : 2nd edition Editeur : Oxford : Oxford University Press Année de publication : 1994 Importance : x, 323 p. ISBN/ISSN/EAN : 978-0-19-502565-1 Langues : Anglais (eng) Tags : DRUGS CANCER CHEMOTHERAPY Index. décimale : EQ -Equipe- Résumé : "This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer. The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. It is extensively referenced and provides a historical background for the development of each class of drugs. The authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine in writing this text." Cote : LCC/K Num_Inv : 1876 The anticancer drugs [texte imprimé] / William B. Pratt, Auteur ; Raymond W. Ruddon, Auteur ; William D. Ensminger, Auteur ; J. Maybaum, Auteur . - 2nd edition . - Oxford : Oxford University Press, 1994 . - x, 323 p.
ISBN : 978-0-19-502565-1
Langues : Anglais (eng)
Tags : DRUGS CANCER CHEMOTHERAPY Index. décimale : EQ -Equipe- Résumé : "This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer. The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. It is extensively referenced and provides a historical background for the development of each class of drugs. The authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine in writing this text." Cote : LCC/K Num_Inv : 1876 Exemplaires(1)
Code-barres Cote Support Localisation Section Disponibilité 1876 LCC/K Texte imprimé Equipe Livre Equipe - Demande préalable
DisponibleThe biochemistry of drug metabolism, Volume 2. Conjugations, consequences of metabolism, influencing factors / Bernard Testa
Titre de série : The biochemistry of drug metabolism, Volume 2 Titre : Conjugations, consequences of metabolism, influencing factors Type de document : texte imprimé Auteurs : Bernard Testa ; Stefanie D. Kramer Editeur : Weinheim : Wiley-VCH Année de publication : 2010 Importance : xiii, 588 p. Présentation : ill. Format : 24 cm ISBN/ISSN/EAN : 978-3-906390-54-3 Langues : Anglais (eng) Catégories : Biochimie Tags : DRUGS METABOLISM Index. décimale : B-F Résumé : "Volume Two contains the last four parts of this work. Part 4 is devoted to the huge field of conjugation reactions, with much information being given on transferases. As in the two preceding parts, each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials. The reactions examined here include methylation, sulfation, glucuronidation, acetylation, conjugation with glutathione, while there is also a rigorous presentation of the pivotal role of xenobiotic-coenzyme A conjugates as a crossroads to various metabolic reactions.
The next part examines the consequences of drug and xenobiotic metabolism in a pharmacological and toxicological perspective, with due attention paid to full activation, as is found with prodrugs, and to the worrying case of xenobiotic toxification.
Parts 6 and 7 cover the inter-individual and intra-individual factors that influence drug metabolism, starting with an introduction to evolutionary events leading to species differences in the metabolism of xenobiotics and to polymorphisms within a particular species. Focusing on humans, the most relevant polymorphic drug-metabolizing enzymes are discussed, concentrating on ethnic differences and on the consequences for the pharmacokinetic behavior of affected drugs, while also introducing sex-dependent metabolic reactions.
The final part introduces the mechanisms leading to increases or decreases in enzyme activities as the concept of enzyme induction via nuclear receptors and the different mechanisms of enzyme inhibition are explained. With these basics in mind, various influencing factors are discussed, including physiological and pathological conditions, as well as drugs, nutrients and environmental agents with a special focus on drug-drug interactions."Cote : B-F034-2 (SdS) Num_Inv : 3061 The biochemistry of drug metabolism, Volume 2. Conjugations, consequences of metabolism, influencing factors [texte imprimé] / Bernard Testa ; Stefanie D. Kramer . - Weinheim : Wiley-VCH, 2010 . - xiii, 588 p. : ill. ; 24 cm.
ISBN : 978-3-906390-54-3
Langues : Anglais (eng)
Catégories : Biochimie Tags : DRUGS METABOLISM Index. décimale : B-F Résumé : "Volume Two contains the last four parts of this work. Part 4 is devoted to the huge field of conjugation reactions, with much information being given on transferases. As in the two preceding parts, each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials. The reactions examined here include methylation, sulfation, glucuronidation, acetylation, conjugation with glutathione, while there is also a rigorous presentation of the pivotal role of xenobiotic-coenzyme A conjugates as a crossroads to various metabolic reactions.
The next part examines the consequences of drug and xenobiotic metabolism in a pharmacological and toxicological perspective, with due attention paid to full activation, as is found with prodrugs, and to the worrying case of xenobiotic toxification.
Parts 6 and 7 cover the inter-individual and intra-individual factors that influence drug metabolism, starting with an introduction to evolutionary events leading to species differences in the metabolism of xenobiotics and to polymorphisms within a particular species. Focusing on humans, the most relevant polymorphic drug-metabolizing enzymes are discussed, concentrating on ethnic differences and on the consequences for the pharmacokinetic behavior of affected drugs, while also introducing sex-dependent metabolic reactions.
The final part introduces the mechanisms leading to increases or decreases in enzyme activities as the concept of enzyme induction via nuclear receptors and the different mechanisms of enzyme inhibition are explained. With these basics in mind, various influencing factors are discussed, including physiological and pathological conditions, as well as drugs, nutrients and environmental agents with a special focus on drug-drug interactions."Cote : B-F034-2 (SdS) Num_Inv : 3061 Réservation
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Code-barres Cote Support Localisation Section Disponibilité 3061 B-F034-2 Texte imprimé Bibliothèque Livre Sorti jusqu'au 17/05/2017 Principes fondamentaux de chimie thérapeutiques / Barret, R.
Titre : Principes fondamentaux de chimie thérapeutiques : médicaments, propriétés physico-chimiques, prodrogues, pharmacophore Type de document : texte imprimé Auteurs : Barret, R., Auteur Année de publication : 2018 Importance : ix, 146 p. ISBN/ISSN/EAN : 978-1-78405-481-6 Langues : Français (fre) Catégories : Biochimie Tags : CHEMOTHERAPY DRUGS Index. décimale : B-F Résumé : Consacré aux principes fondamentaux de la chimie thérapeutique, cet ouvrage donne une définition du médicament, décrit la vie du principe actif et analyse les propriétés physicochimiques des médicaments (pKa, lipophilie, solubilité et surface polaire), leurs évaluations et leurs intérêts dans le drug-design.
Il présente le principe de prodrogue en décrivant ses différents types (bioprécurseurs, prodrogues à vecteur) ainsi que ses applications pour le drug-design et dans les théories ADEPT et GDEPT. La notion de pharmacophore 2D et 3D est examinée en détail et les règles de Lipinsky complètent la description des principes fondamentaux. Enfin, il analyse de manière minutieuse la pharmacopée européenne et précise le rôle de celle-ci dans le domaine industriel.
Principes fondamentaux de chimie thérapeutique s’adresse aussi bien aux étudiants de pharmacie qu’à ceux de différents masters ayant pour thème la conception et l’analyse, la pharmacocinétique, et dans une certaine mesure la pharmacologie du médicament.Note de contenu : "* Le médicament
* Importance et évaluation du pKa
* Importance et évaluation de la lipophilie
* Importance et évaluation de la solubilité
* Importance et évaluation de la surface polaire (PSA et TPSA)
* Paramètres de Lipinski
* Principe de prodrogue
* Le pharmacophore
* La Pharmacopée européenne".Cote : B-F053 Num_Inv : 3541 Localisation : LCC (SdS) Principes fondamentaux de chimie thérapeutiques : médicaments, propriétés physico-chimiques, prodrogues, pharmacophore [texte imprimé] / Barret, R., Auteur . - 2018 . - ix, 146 p.
ISBN : 978-1-78405-481-6
Langues : Français (fre)
Catégories : Biochimie Tags : CHEMOTHERAPY DRUGS Index. décimale : B-F Résumé : Consacré aux principes fondamentaux de la chimie thérapeutique, cet ouvrage donne une définition du médicament, décrit la vie du principe actif et analyse les propriétés physicochimiques des médicaments (pKa, lipophilie, solubilité et surface polaire), leurs évaluations et leurs intérêts dans le drug-design.
Il présente le principe de prodrogue en décrivant ses différents types (bioprécurseurs, prodrogues à vecteur) ainsi que ses applications pour le drug-design et dans les théories ADEPT et GDEPT. La notion de pharmacophore 2D et 3D est examinée en détail et les règles de Lipinsky complètent la description des principes fondamentaux. Enfin, il analyse de manière minutieuse la pharmacopée européenne et précise le rôle de celle-ci dans le domaine industriel.
Principes fondamentaux de chimie thérapeutique s’adresse aussi bien aux étudiants de pharmacie qu’à ceux de différents masters ayant pour thème la conception et l’analyse, la pharmacocinétique, et dans une certaine mesure la pharmacologie du médicament.Note de contenu : "* Le médicament
* Importance et évaluation du pKa
* Importance et évaluation de la lipophilie
* Importance et évaluation de la solubilité
* Importance et évaluation de la surface polaire (PSA et TPSA)
* Paramètres de Lipinski
* Principe de prodrogue
* Le pharmacophore
* La Pharmacopée européenne".Cote : B-F053 Num_Inv : 3541 Localisation : LCC (SdS) Exemplaires(1)
Code-barres Cote Support Localisation Section Disponibilité 3541 B-F053 Texte imprimé Bibliothèque Livre Disponible The biochemistry of drug metabolism, Volume 1. Principles, redox reactions, hydrolyses / Bernard Testa
Titre de série : The biochemistry of drug metabolism, Volume 1 Titre : Principles, redox reactions, hydrolyses Type de document : texte imprimé Auteurs : Bernard Testa ; Stefanie D. Kramer Editeur : Weinheim : Wiley-VCH Année de publication : 2008 Importance : xiii, 319 p. Présentation : ill. Format : 24 cm ISBN/ISSN/EAN : 978-3-906390-53-6 Langues : Anglais (eng) Catégories : Biochimie Tags : DRUGS METABOLISM Index. décimale : B-F Résumé : "The first of the two volumes is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug metabolism in animals and humans. This is followed by an introduction to the all-important issue of the consequences of drug and xenobiotic metabolism, providing an initial overview of pharmacokinetic, pharmacological and toxicological consequences. The last chapter examines drug metabolism in the context of drug research, with a focus on medicinal chemistry.
The second part is a major component of the book, corresponding to the role of oxidoreductases as major agents of metabolism. Cytochromes P450 receive particular attention, namely their multiplicity, structure, catalytic mechanisms, and the various reactions they catalyze, while other oxidoreductases are also presented, such as flavin monooxygenases, monoamine oxidases and other amine oxidases, aldehyde oxidase and xanthine dehydrogenase, peroxidases, and dehydrogenases-reductases. Each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials.
Part Three begins with a survey of the classification, properties and catalytic mechanism of the innumerable hydrolases known or suspected to play a role in xenobiotic metabolism. The focus then shifts to a systematic presentation of the various substrate classes, namely carboxylic esters, amides and peptides, lactams and lactones, esters of inorganic acids, alkene and arene epoxides, and some miscellaneous hydrolyzable moieties."Cote : B-F034-1 (SdS) Num_Inv : 3060 The biochemistry of drug metabolism, Volume 1. Principles, redox reactions, hydrolyses [texte imprimé] / Bernard Testa ; Stefanie D. Kramer . - Weinheim : Wiley-VCH, 2008 . - xiii, 319 p. : ill. ; 24 cm.
ISBN : 978-3-906390-53-6
Langues : Anglais (eng)
Catégories : Biochimie Tags : DRUGS METABOLISM Index. décimale : B-F Résumé : "The first of the two volumes is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug metabolism in animals and humans. This is followed by an introduction to the all-important issue of the consequences of drug and xenobiotic metabolism, providing an initial overview of pharmacokinetic, pharmacological and toxicological consequences. The last chapter examines drug metabolism in the context of drug research, with a focus on medicinal chemistry.
The second part is a major component of the book, corresponding to the role of oxidoreductases as major agents of metabolism. Cytochromes P450 receive particular attention, namely their multiplicity, structure, catalytic mechanisms, and the various reactions they catalyze, while other oxidoreductases are also presented, such as flavin monooxygenases, monoamine oxidases and other amine oxidases, aldehyde oxidase and xanthine dehydrogenase, peroxidases, and dehydrogenases-reductases. Each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials.
Part Three begins with a survey of the classification, properties and catalytic mechanism of the innumerable hydrolases known or suspected to play a role in xenobiotic metabolism. The focus then shifts to a systematic presentation of the various substrate classes, namely carboxylic esters, amides and peptides, lactams and lactones, esters of inorganic acids, alkene and arene epoxides, and some miscellaneous hydrolyzable moieties."Cote : B-F034-1 (SdS) Num_Inv : 3060 Réservation
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Code-barres Cote Support Localisation Section Disponibilité 3060 B-F034-1 Texte imprimé Bibliothèque Livre Sorti jusqu'au 17/05/2017