4 recherche sur le tag 'METALS-Therapeutic use'   

Ligand design in medicinal inorganic chemistry / Tim Storr

Public ISBD Titre : Ligand design in medicinal inorganic chemistry Type de document : texte imprimé Auteurs : Tim Storr, Éditeur scientifique Editeur : Chichester : John Wiley & Sons Année de publication : 2014 Importance : xvii, 449 p. ISBN/ISSN/EAN : 978-1-118-48852-2 Langues : Anglais (eng) Catégories : Biochimie Tags : METALS-Therapeutic use  METALS IN MEDICINE  PHARMACEUTICAL CHEMISTRY  DNA-Drug interactions Index. décimale : B-F Note de contenu : "* Introduction to ligand design in medicinal inorganic chemistry * Platinum-based anticancer agents * Coordination chemistry and ligand design in the development of metal based radiopharmaceuticals * Ligand design in d-block optical imaging agents and sensors * Luminescent lanthanoid probes * Metal complexes of carbohydrate-targeted ligands in medicinal inorganic chemistry * Design of schiff base-derived ligands: Applications in therapeutics and medical diagnosis * Metal-based antimalarial agents * Therapeutic gold compounds * Ligand design to target and modulate metal–protein interactions in neurodegenerative diseases * Rational design of copper and iron chelators to treat Wilson’s disease and hemochromatosis * MRI contrast agents * Photoactivatable metal complexes and their use in biology and medicine * Metalloprotein inhibitors * Ruthenium anticancer compounds with biologically-derived ligands." Cote : B-F040 (SdS) Num_Inv : 3416 Ligand design in medicinal inorganic chemistry [texte imprimé] / Tim Storr, Éditeur scientifique . - Chichester : John Wiley & Sons, 2014 . - xvii, 449 p. ISBN : 978-1-118-48852-2 Langues : Anglais (eng) Catégories : Biochimie Tags : METALS-Therapeutic use  METALS IN MEDICINE  PHARMACEUTICAL CHEMISTRY  DNA-Drug interactions Index. décimale : B-F Note de contenu : "* Introduction to ligand design in medicinal inorganic chemistry * Platinum-based anticancer agents * Coordination chemistry and ligand design in the development of metal based radiopharmaceuticals * Ligand design in d-block optical imaging agents and sensors * Luminescent lanthanoid probes * Metal complexes of carbohydrate-targeted ligands in medicinal inorganic chemistry * Design of schiff base-derived ligands: Applications in therapeutics and medical diagnosis * Metal-based antimalarial agents * Therapeutic gold compounds * Ligand design to target and modulate metal–protein interactions in neurodegenerative diseases * Rational design of copper and iron chelators to treat Wilson’s disease and hemochromatosis * MRI contrast agents * Photoactivatable metal complexes and their use in biology and medicine * Metalloprotein inhibitors * Ruthenium anticancer compounds with biologically-derived ligands." Cote : B-F040 (SdS) Num_Inv : 3416

Exemplaires(1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
3416	B-F040	Texte imprimé	Bibliothèque	Livre	Disponible

Metals in medicine / James C. Dabrowiak

Public ISBD Titre : Metals in medicine Type de document : texte imprimé Auteurs : James C. Dabrowiak Editeur : Hoboken : Wiley Année de publication : 2009 Importance : 320 p. Présentation : ill. Format : 26 cm ISBN/ISSN/EAN : 978-0-470-68196-1 Langues : Anglais (eng) Catégories : Biochimie Tags : METALS-Therapeutic use Index. décimale : B-F Résumé : "Working from basic chemical principles, Metals in Medicine presents a complete and methodical approach to the topic. Introductory chapters discuss important bonding concepts applicable to metallo-drugs and their biological targets, interactions that exist between the agents and substances in the biological milieu, basic pharmacokinetic and pharmacodynamic properties including transport and uptake of drugs by the cells, and methods for measuring efficacy and toxicity of agents. The steps from drug discovery to market place are also briefly outlined and discussed. These chapters lay the groundwork, in order that students can clearly understand how agents work, whatever their subject background." Cote : B-F033 (SdS) Num_Inv : 2970 Metals in medicine [texte imprimé] / James C. Dabrowiak . - Hoboken : Wiley, 2009 . - 320 p. : ill. ; 26 cm. ISBN : 978-0-470-68196-1 Langues : Anglais (eng) Catégories : Biochimie Tags : METALS-Therapeutic use Index. décimale : B-F Résumé : "Working from basic chemical principles, Metals in Medicine presents a complete and methodical approach to the topic. Introductory chapters discuss important bonding concepts applicable to metallo-drugs and their biological targets, interactions that exist between the agents and substances in the biological milieu, basic pharmacokinetic and pharmacodynamic properties including transport and uptake of drugs by the cells, and methods for measuring efficacy and toxicity of agents. The steps from drug discovery to market place are also briefly outlined and discussed. These chapters lay the groundwork, in order that students can clearly understand how agents work, whatever their subject background." Cote : B-F033 (SdS) Num_Inv : 2970

Exemplaires(1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
2970	B-F033	Texte imprimé	Bibliothèque	Livre	Disparu Exclu du prêt

Design of hybrid molecules for drug development / Decker, Michael

Public ISBD Titre : Design of hybrid molecules for drug development Type de document : texte imprimé Auteurs : Decker, Michael, Éditeur scientifique Editeur : Amsterdam : Elsevier Année de publication : 2017 Importance : xiii, 338 p. ISBN/ISSN/EAN : 978-0-08-101011-2 Note générale : Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied Compares the advantages and disadvantages of these compounds Includes the very latest developments, such as photoactivatable and photo-responsive drugs Langues : Anglais (eng) Catégories : Biochimie Tags : METALS-THERAPEUTIC USE  DRUG-THERAPY  CANCER DRUG  MOLECULAR BIOLOGY Index. décimale : B-F Résumé : Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. Note de contenu : " * Multitarget-Directed Antioxidants as Therapeutic Agents: Putting the Focus on the Oxidative Stress * Towards Gaseous Mediator Hybrid Drugs * Designed Hybrid Compounds for Tropical Parasitic Diseases * Dual-Acting Compounds Acting as Receptor Ligands and Enzyme Inhibitors * Multitarget Anti-Alzheimer Hybrid Compounds: Do They Work In Vivo? * Anticancer Hybrids * Molecular Hybridization: An Emerging Tool for the Design of Novel Therapeutics for Alzheimer’s Disease * Computational Methods in Multitarget Drug Discovery * Medicinal Chemistry of Hybrids for Neurodegenerative Diseases * Photoresponsive Hybrid Compounds". Cote : B-F050 Num_Inv : 3511 Localisation : LCC (SdS) Design of hybrid molecules for drug development [texte imprimé] / Decker, Michael, Éditeur scientifique . - Amsterdam : Elsevier, 2017 . - xiii, 338 p. ISBN : 978-0-08-101011-2 Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied Compares the advantages and disadvantages of these compounds Includes the very latest developments, such as photoactivatable and photo-responsive drugs Langues : Anglais (eng) Catégories : Biochimie Tags : METALS-THERAPEUTIC USE  DRUG-THERAPY  CANCER DRUG  MOLECULAR BIOLOGY Index. décimale : B-F Résumé : Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. Note de contenu : " * Multitarget-Directed Antioxidants as Therapeutic Agents: Putting the Focus on the Oxidative Stress * Towards Gaseous Mediator Hybrid Drugs * Designed Hybrid Compounds for Tropical Parasitic Diseases * Dual-Acting Compounds Acting as Receptor Ligands and Enzyme Inhibitors * Multitarget Anti-Alzheimer Hybrid Compounds: Do They Work In Vivo? * Anticancer Hybrids * Molecular Hybridization: An Emerging Tool for the Design of Novel Therapeutics for Alzheimer’s Disease * Computational Methods in Multitarget Drug Discovery * Medicinal Chemistry of Hybrids for Neurodegenerative Diseases * Photoresponsive Hybrid Compounds". Cote : B-F050 Num_Inv : 3511 Localisation : LCC (SdS)

Exemplaires(1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
3511	B-F050	Texte imprimé	Bibliothèque	Livre	Disponible

Advanced inorganic chemistry - Applications in everyday life / Narayan S. Hosmane

Public ISBD Titre : Advanced inorganic chemistry - Applications in everyday life Type de document : texte imprimé Auteurs : Narayan S. Hosmane, Auteur Editeur : London : Academic Press Année de publication : 2017 Importance : xii, 255 p. ISBN/ISSN/EAN : 978-0-12-801982-5 Note générale : * Engaging discussion of key concepts with examples from the real world * Valuable coverage from the foundations of chemical bonds and stereochemistry to advanced topics, such as organometallic, bioinorganic, carboranes and environmental chemistry * Uniquely begins with a focus on the shapes (geometry) dictating intermolecular forces of attractions, leading to reactivity between molecules of different shapes Langues : Anglais (eng) Catégories : Chimie de coordination, Chimie organométallique, Métaux de transition Tags : INORGANIC CHEMOLECULAR THEORYMISTRY  INORGANIC CHEMISTRY-HANDBOOK  INORGANIC CHEMISTRY-TECHNIQUES  MOLECULAR ORBITALS  METALS-THERAPEUTIC USE Index. décimale : B-D Résumé : Advanced Inorganic Chemistry: Applications in Everyday Life connects key topics on the subject with actual experiences in nature and everyday life. Differing from other foundational texts with this emphasis on applications and examples, the text uniquely begins with a focus on the shapes (geometry) dictating intermolecular forces of attractions, leading to reactivity between molecules of different shapes. From this foundation, the text explores more advanced topics, such as: Ligands and Ligand Substitution Processes with an emphasis on Square-Planar Substitution and Octahedral Substitution Reactions in Inorganic Chemistry and Transition Metal Complexes, with a particular focus on Crystal-Field and Ligand-Field Theories, Electronic States and Spectra and Organometallic, Bioinorganic Compounds, including Carboranes and Metallacarboranes and their applications in Catalysis, Medicine and Pollution Control. Throughout the book, illustrative examples bring inorganic chemistry to life. For instance, biochemists and students will be interested in how coordination chemistry between the transition metals and the ligands has a direct correlation with cyanide or carbon monoxide poisoning (strong-field Cyanide or CO ligand versus weak-field Oxygen molecule). Note de contenu : "* Foundations: Concepts in Chemical Bonding and Stereochemistry * Introduction to Ligands and Metal Complexes * Electronic Spectra, Clusters & Isolobal Fragments * Organometallic Chemistry and Catalysis * Bioinorganic Chemistry and Applications" Cote : B-D197 Num_Inv : 3503 Advanced inorganic chemistry - Applications in everyday life [texte imprimé] / Narayan S. Hosmane, Auteur . - London : Academic Press, 2017 . - xii, 255 p. ISBN : 978-0-12-801982-5 * Engaging discussion of key concepts with examples from the real world * Valuable coverage from the foundations of chemical bonds and stereochemistry to advanced topics, such as organometallic, bioinorganic, carboranes and environmental chemistry * Uniquely begins with a focus on the shapes (geometry) dictating intermolecular forces of attractions, leading to reactivity between molecules of different shapes Langues : Anglais (eng) Catégories : Chimie de coordination, Chimie organométallique, Métaux de transition Tags : INORGANIC CHEMOLECULAR THEORYMISTRY  INORGANIC CHEMISTRY-HANDBOOK  INORGANIC CHEMISTRY-TECHNIQUES  MOLECULAR ORBITALS  METALS-THERAPEUTIC USE Index. décimale : B-D Résumé : Advanced Inorganic Chemistry: Applications in Everyday Life connects key topics on the subject with actual experiences in nature and everyday life. Differing from other foundational texts with this emphasis on applications and examples, the text uniquely begins with a focus on the shapes (geometry) dictating intermolecular forces of attractions, leading to reactivity between molecules of different shapes. From this foundation, the text explores more advanced topics, such as: Ligands and Ligand Substitution Processes with an emphasis on Square-Planar Substitution and Octahedral Substitution Reactions in Inorganic Chemistry and Transition Metal Complexes, with a particular focus on Crystal-Field and Ligand-Field Theories, Electronic States and Spectra and Organometallic, Bioinorganic Compounds, including Carboranes and Metallacarboranes and their applications in Catalysis, Medicine and Pollution Control. Throughout the book, illustrative examples bring inorganic chemistry to life. For instance, biochemists and students will be interested in how coordination chemistry between the transition metals and the ligands has a direct correlation with cyanide or carbon monoxide poisoning (strong-field Cyanide or CO ligand versus weak-field Oxygen molecule). Note de contenu : "* Foundations: Concepts in Chemical Bonding and Stereochemistry * Introduction to Ligands and Metal Complexes * Electronic Spectra, Clusters & Isolobal Fragments * Organometallic Chemistry and Catalysis * Bioinorganic Chemistry and Applications" Cote : B-D197 Num_Inv : 3503

Exemplaires(1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
3503	B-D197	Texte imprimé	Bibliothèque	Livre	Disponible