| Titre : |
Copper-catalyzed amination of aryl and alkenyl electrophiles |
| Type de document : |
texte imprimé |
| Auteurs : |
Shaughnessy, Kevin H., Auteur ; Ciganek, Engelbert, Auteur ; DeVasher, Rebecca, B., Auteur |
| Editeur : |
Wiley-VCH Verlag |
| Année de publication : |
2017 |
| Importance : |
ix, 679 p. |
| ISBN/ISSN/EAN : |
978-1-119-34598-5 |
| Note générale : |
The contents of the book are taken from the comprehensive review of the topic in the Organic Reactions series. Optimal experimental conditions for the amination of aryl and alkenyl halides with all classes of nitrogen nucleophiles are presented. Specific experimental procedures from the literature are provided for the major classes of copper-catalyzed C?N coupling reactions. A tabular survey of all examples of Cu-catalyzed arylation and alkenylation of nitrogen nucleophiles is presented in 35 tables organized by nitrogen nucleophile and electrophilic coupling partner.
|
| Langues : |
Anglais (eng) |
| Catégories : |
Catalyse
|
| Tags : |
METAL CATALYSIS CATALYSIS |
| Index. décimale : |
B-E |
| Résumé : |
The metal-catalyzed amination of aryl and alkenyl electrophiles has developed into a widely used methodology for the synthesis of natural products, active pharmaceutical ingredients, agricultural chemicals, and materials for molecular electronics. Copper catalysts promote the coupling of a wide range of nitrogen nucleophiles, including amines, amides, and heteroaromatic nitrogen compounds with aryl and alkenyl halides. The reactivity profile of copper catalysts is complementary to that of palladium catalysts in many cases. Copper catalysts are highly effective with less nucleophilic nitrogen nucleophiles, such as amides and azoles, whereas palladium catalysts are more effective with more nucleophilic amine nucleophiles. Copper is an attractive alternative to palladium due to its significantly lower cost. In addition, high activity palladium catalysts require expensive and often air-sensitive ligands, whereas the modern copper systems use relatively stable and inexpensive diamine or amino acid ligands. Copper-catalyzed C?N coupling reactions are tolerant of a wide range of functional groups and have been applied to the synthesis of a variety of complex natural products. Significant work has also been done to understand the mechanism of these reactions. Current mechanistic understanding of these methodologies is covered in this monograph. |
| Note de contenu : |
" Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles". |
| Cote : |
B-E094 |
| Num_Inv : |
3558 |
| Localisation : |
LCC (SdS) |
Copper-catalyzed amination of aryl and alkenyl electrophiles [texte imprimé] / Shaughnessy, Kevin H., Auteur ; Ciganek, Engelbert, Auteur ; DeVasher, Rebecca, B., Auteur . - Wiley-VCH Verlag, 2017 . - ix, 679 p. ISBN : 978-1-119-34598-5 The contents of the book are taken from the comprehensive review of the topic in the Organic Reactions series. Optimal experimental conditions for the amination of aryl and alkenyl halides with all classes of nitrogen nucleophiles are presented. Specific experimental procedures from the literature are provided for the major classes of copper-catalyzed C?N coupling reactions. A tabular survey of all examples of Cu-catalyzed arylation and alkenylation of nitrogen nucleophiles is presented in 35 tables organized by nitrogen nucleophile and electrophilic coupling partner.
Langues : Anglais ( eng)
| Catégories : |
Catalyse
|
| Tags : |
METAL CATALYSIS CATALYSIS |
| Index. décimale : |
B-E |
| Résumé : |
The metal-catalyzed amination of aryl and alkenyl electrophiles has developed into a widely used methodology for the synthesis of natural products, active pharmaceutical ingredients, agricultural chemicals, and materials for molecular electronics. Copper catalysts promote the coupling of a wide range of nitrogen nucleophiles, including amines, amides, and heteroaromatic nitrogen compounds with aryl and alkenyl halides. The reactivity profile of copper catalysts is complementary to that of palladium catalysts in many cases. Copper catalysts are highly effective with less nucleophilic nitrogen nucleophiles, such as amides and azoles, whereas palladium catalysts are more effective with more nucleophilic amine nucleophiles. Copper is an attractive alternative to palladium due to its significantly lower cost. In addition, high activity palladium catalysts require expensive and often air-sensitive ligands, whereas the modern copper systems use relatively stable and inexpensive diamine or amino acid ligands. Copper-catalyzed C?N coupling reactions are tolerant of a wide range of functional groups and have been applied to the synthesis of a variety of complex natural products. Significant work has also been done to understand the mechanism of these reactions. Current mechanistic understanding of these methodologies is covered in this monograph. |
| Note de contenu : |
" Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles". |
| Cote : |
B-E094 |
| Num_Inv : |
3558 |
| Localisation : |
LCC (SdS) |
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